Flashcards in W15_03 substance abuse Deck (15)
what are the anatomical structures involved in addiction?
medial forebrain bundle;
dopamine is the neurotransmitter
note: cocaine acts on the reward pathway directly, so it has a huge effect
what are some of the characteristics that make drugs addictive?
potency at receptor;
short duration of action;
note: tolerance blah balh
positive famil history increases risk of alcohol dependence. How does this affect the response to alcohol in the individual?
fewer adverse effects (e.g. hangover);
more positive effects
note: many mental disorders are linked with addiction
the drugs help them get out of their disorders
note: for addicts, their lives often focus and revolve around getting and using the drugs
what are the 4 Cs of drug use?
compulsive drug use;
inability to cut down;
continued use despite consequences
how to take a substance use history? (I P TARRR)
pattern of use;
readiness to change
note: risk of CAD after quitting smoking dec 50% in one year
risk of stroke normalizes after 5 years
what does nicotine cause pharmacologically?
psychoactive effects in pleasure, arousal, relaxation, anxiety relief;
CV effects of increase HR, cardiac output, BP, but coronary/cutaneous vasoconstriction;
increased metabolic rate
what are the 5 As of initiating smoking cessation
arrange follow up
what are some pharmacotherapies for quitting smoking?
nicotine replacement therapy;
what's buproprion? (smoking cessation)
atypical antidepressant thought to elevate dopamine levels in mesolimbic system and nucleus accumbens