Week 4 Muscle Paralytics- Trachte Flashcards Preview

Skin/ Musculoskeletal > Week 4 Muscle Paralytics- Trachte > Flashcards

Flashcards in Week 4 Muscle Paralytics- Trachte Deck (10):
1

Botulinum Toxin

destroys components of the docking apparatus that are required for vesicle fusion in neurons that untilze acetylcholine as a neurotransmitter: PREVENTS MUSCLE CONTRACTION

2

**Anticholinesterases (pyridostigmine, neostigmine,endrophonium)

Inhibits cholinesterases (reversible!) increase acetylcholine concentrations in the vicinity of the nicotinic receptor

Treatment for myasthenia gravis

3

What activates a nicotinic receptor?

NICOTINE and acteylcholine

4

d-tubocurarine, Mivacurium

Nicotinic receptor antagonist/ competitive blocker. Blocks acetylcholine from binding to nicotinic receptor
-used for surgery

5

Dantrolene

block calcium-induced calcium release from sarcoplasmic reticulum by inhibiting the ryanodine receptor (in skeletal muscle)

-Action potential would stay the same!!! MOA would come after the action potential

6

Nerve gases/ insecticides

-block acetycholinesterases.- (irreversible!)
-causes Ach to linger in synaptic cleft
-prolongs postsynaptic depolarization
-sustained exposure to AchE inhibitors causes desensitization
-post-synpatic cell fails to respond to ACh
-paraylysis

7

**Toxicity of anticholinesterases

SLUDGE
sweating
lacrimation
urination
diarrhea
GI distress
emesis

8

Succinylcholine

depolarizing agent, nicotinic receptor antagonist

9

Malignant hyperthermia

-mutation ryanodine receptor.
-Can't control levels of cytosolic calcium when given anestetics like succinylcholine
-show marked hyperbolic state (tachycarida, tachypena, muscle spasms)
-to reverse give dantolene which inhibits the ryanodine receptor and stops release of calcium

10

Biotoxins

target VG Na+ channels results in paralysis