Week 4 Soft-tissue tumors- Nelson Flashcards Preview

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Flashcards in Week 4 Soft-tissue tumors- Nelson Deck (20):
1

Describe in one or two sentences the classification scheme for mesenchymal/ soft tissue tumors.

Soft-tissue tumors are classified by the types of tissue that they recapitulate or differentiate to, they be divided into benign and malignant (sarcoma) forms.

2

Describe the typical pattern of spread of sarcomas when they metastasize

a. Benign soft-tissue tumors outnumber malignant soft-tissue tumors
b. Sarcomas are rare but deadly
c. Usually metastasize via hematogenous routes (to lung and bone)

3

State the type of cell that gives rise to soft tissue tumors

mesenchymal cells

4

Most common type of genetic abnormalitiy in soft tissue tumors?

Specific chromosomal abnormalities, usually translocations!

5

Which imaging technique is most helpful in assessment of soft tissue tumors or extrememties?

MRI

6

Lipoma

benign fatty tumor

7

Liposarcoma

malignant fatty tumor

8

Pseudosarcomatous proliferations

benign lesion following local trauma/ injury

9

Superficial fibromatoses

benign fibroblastic proliferation involving fascia or aponeruoses

10

Deep-seated fibromatoses

benign fibroblastic proliferation, but can reoccur

11

Fibrosarcoma

malignant, sarcomatous tumors of fibroblasts

12

Rhabdomyoma

benign tumor showing skeletal muscle differentiation

13

Rhabdomyosarcoma

malignant tumor showing skeletal muscle differentiation

14

Leimyoma

benign tumor showing smooth muscle differentiation

15

Leiomyosarcoma

malignant tumor showing smooth muscle differentiation

16

hemangioma

benign lesion of blood vessel

17

lymphangioma

benign lesion of lympathics

18

Angiosarcoma

malignant. Showing endothelial differentiation

19

Hemangioendotheliomas

malignant vascular tumors

20

Differences between NF1 and NF2

NF1: more common, mutation of chromosome 17 coding for neurofibromin (tumor suppressor)

NF2: less common, mutation of chromosome 22 coding merline (regulates membrane receptor signaling, tumor suppressor)