Week 5 Arachinodic Acid- Trachte Flashcards Preview

Skin/ Musculoskeletal > Week 5 Arachinodic Acid- Trachte > Flashcards

Flashcards in Week 5 Arachinodic Acid- Trachte Deck (14):
1

What enzyme is most likely to release arachidonic acid from membrane?

Phospholipase A2

2

What molecule mediated inflammation? Pain, Fever, vasodilation, uterine contraction

Prostaglandin E2

3

What would cause mycoardial infarction?

Increase Thromboxane A2
(Or decrease Prostacyclin which prevents platelet aggregation)

4

COX 2 inhibitors would block synthesis of what molecule?

Prostacyclin - likely to cause myocardial infarction

5

Acetylsalicylic acid

(Asprin) Irreversible inhibitor of thromboxane synthanse. Does some inhibition of COX1 and COX2
- give to reduce MI or stroke (eliminate thrombosis)

6

Celecoxib

(Celebrex)
-COX2 specific inhibitor
-less gastric ulceration
-Suppressed prostacyclin synthesis
-Most COX2 inhibitors have been taken off market because they cause MIs

7

Acetaminophen

Blocks COXs in central nervous system
-not in periphery
-NOT ANTI-INFLAMMATORY

8

What molecule mediates many inflammatory effects of rheumatoid arthritis?

Prostaglandins
-treat with ibuprofen and NSAIDs
-but DO NOT HALT disease progression

9

How do corticosteroids work?

-transcriptional regulators
-Reduce number of WBC
-Reduces release of arachidonic acid from membrane
-Inhibits prostaglandin and leukotriene synthesis

10

Dexamethasone
Hydrocortisone
Methylprednisolone
Prednisone

Corticosteroids

11

What suppresses both prostaglandin and leukotriene synthesis?

Cortiocosteroids

12

What relieves arthritis symptoms by reversilby blocking prostaglandin synthesis?

ibuprofen (Cox inhibitor)

13

What relieves arthritis symptoms and reduceds risk of MI?

Acetylsalicylic acid (aspirin)

14

What relieves arthritis treatment with the least risk of gastric ulceration?

Celecoxib