Week 6 Anti-neoplastic drugs- Fitz Flashcards Preview

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Flashcards in Week 6 Anti-neoplastic drugs- Fitz Deck (14):
1

What do you give to prevent hemorragic cystitis?

MESA (binds acroleint)

2

What drugs need to be converted to active form in the liver?

Melphalan
Cyclophosphamide
Etoposide

3

What are Melphalan/cyclophosphamide converted into?

Phosphoramide mustard (anti-neoplastic)
Acroleint (not active) - causes hemorragic cysitis

4

Why is hydration important when taking melphalan/ cyclophosphamide?

Helps to dilute acroleint, and increase excretion

5

Side affects of methotrexate?

bone marrow suppression
nephro and hepato toxicity

6

What three things support methotrexate administration?

- hydration
-its a weak acid, will secret more if urine is alkalinated
-glucarpidase increases methotrexate degredation
-Leucoviorin- makes it so normal cells can bypass DHFR, rescue treatment for normal cells

7

Leucoviorin

makes it so normal cells can bypass DHFR

rescue treatment for normal cells

8

Arac-C

mimics ATP to block pyrimidine synthesis (treated acute myloid leukemia)

9

Fludarabine

mimics ATP to block purine synthesis (treated acute myloid leukemia)

10

Cyclophosphamide

alkylating agent that causes DNA crosslinking
-give with Mesna to bind acrolein
-NON SPECIFIC

11

Cisplatin

platinus causes DNA crosslinking
-NON SPECIFIC

12

Ifosfamide

alkylating agent that causes DNA crosslinking
-NON SPECIFIC

13

Busulfan

alkylating agent that causes DNA crosslinking
-NON SPECIFIC

14

glucarpidase

increases methotrexate degredation