Week 4 Parasites-Zimmer Flashcards Preview

Skin/ Musculoskeletal > Week 4 Parasites-Zimmer > Flashcards

Flashcards in Week 4 Parasites-Zimmer Deck (14):
1

Sub-Saharan Africa
Nodules under skin
Hyperpigmented skin
Severe Itching
Inflammation of cornea (can lead to permanent blindness)

Onchocerciasis (river blindness)

2

How would you treat onchocerciases? (river blindness)

Ivermectin: binds to and blocks glutamate-gated chloride channels
-effective against microfilaria
-little affect on adult worms (retreatment is required an annual intervals)

3

East Africa, Asia, Latin America
Ulcerative skin lesion with raised outer bordered

Cutaneous Leishmaniasis (lives in macrophages)

4

Marked splenomegaly
Weight loss
Low blood cell count (WBC,RBC, platelet)

Visceral Leishmaniasis

5

How do you diagnose/ treat leishmaniasis

CDC involved! Microscopic detection

Treatment= Sodium stibogluconate/ Meglumine antimoniate (MOA not understood)

6

Often asymptomatic, but at chronic stage can develope myocarditis, megaesophagus and megacolon

Chaga's Disease

7

Treatment for Chaga's Disease?

Nifurtimox/ Benznidozole: induces oxidative stress due to inhibiton of NADPH -dependent dehydrogenases

*requires Type 1 nitroreductase to turn prodrug into active form

8

Chancre at site of bite
headache/fever/swollen lymph nodes
Muschle and joint aches
CNS involvement
Somnolence
Altered gate

Africa Trypanosomiasis

9

How do you differentiate T. cruzi from T. brucei?

T. brucie multiple by binary fission in various body fluids/ bloodstream

10

How do you treat African Trypanosiamsis?

Suramin: inhibitory effect on enzymes of the pentose phosphate and glycolytic pathways

11

Asia, Africa, Western pacific, Caribbean
Lympedema
Elephantits
Hydrocele

Lymphatic filariasis

12

How do you treat lymphatic filariasis?

Diethlcarbamazine: arachidonic acid metabolic mathway of microfilaria

-kills microfilaria and some adult worms

13

Toxoplasmosis

oocyst from cat feces
mostly asymptomatic
Neutropic parasite, intracellular encystment in the host muscle and brain cells
-watch immunocompromised, and pregos

14

How do you treat toxoplasmosis?

Atovaquone
Sulfadiazine and pryimethamine