Week 3 Derm Therapuetics- Evanson Flashcards Preview

Skin/ Musculoskeletal > Week 3 Derm Therapuetics- Evanson > Flashcards

Flashcards in Week 3 Derm Therapuetics- Evanson Deck (29):
1

What provides the "bricks and mortar" barrier for the skin and is the rate-limiting step to topical therapy absorption?

Stratum corneum

2

What increase absorption by making the stratum corneum more penetrable?

hydration

3

What determines the level of occlusiveness and absorption?

The vehicle (cream vs. oinment)

4

What is an adverse affect of corticosteroids?

SKIN ATROPHY

5

What drug is a vitamin A analog?

Retinoids

6

What drug is a vitamin D analog?

Calcipotriene

7

Why do newer sunscreens work better against UVA?

They have avobenzone/helioplex or Mexoryl

8

What does SPF stand for? And which SPF blocks out 97% of the suns UV rays?

sun protection factor
SPF 30

9

MOA of Imiquidmod: Aldara cream

Immune response modifier

10

What does 5-FU inhibit?

thymidylate synthase

11

How should you care for a wound in general?

keep it covered with nonstick dressing to allow natural cytokines to facilitate healing

12

What does methotrexate inhibit? Major side effect?

Dihydrofolate reducatase inhibitor. Hepatotoxicity

13

Three stages of normal hair cycle?

Anagen to catagen to telogen

14

What is Telogen effluvium?

stress hair loss

15

What causes androgenetic alopecia?

genetically determined miniaturization of follicles trigged by androgens

16

What is alopecia areata?

Autoimmune, T-cells attack the hair bulb

17

What is secondary alopecia?

diffuse hair thinning as a complication of an existing medication or medical problem

18

How do you treat tinea capitis?

griseofulvin

19

Mechanism of Action of Retinoids?

Regulates cell growth, repairs disordered keratinization

20

Clicpotriene

vitamin D analog
alters skin differentiation
Use for psoriasis

21

Topical calcineruin

NSAID, alters T-cell activation
Use for eczema, dermatitis

22

Imiquidmod: Aldara cream

Increases immune system

23

Topical 5-fluorouracil

Thymidalate Synthase
Reduced DNA synthesis
For actinic keratosis

24

Dapsone

Use for neutrophilic skin diseases

25

Methotrexate
Side effect?

Dihydrofolate reducatse inhibitor
Side effect- hepatotoxicity

26

Biological Therapy

Biogenetically engineered proteins which disrupt/ inhibit focused portions of the immune system involved in psoriasis

27

UV Light Therapy
What do you use for?

Forms pyrimidine dimers in DNA and reduced langerhans cell and leukocytes. Anti-inflammatory and immunosuppressive
For psoriasis, pruritus, eczema

28

Minoxidil

Rogaine
Vasodilation and direct stimulation of hair shaft growth
alopecia

29

Finasterida

Blocks 5 alpha reductase enzyme in follicles to inhibit the conversion of testosterone to dihydrotestosterone
For androgenic alopecia