Wk 5 Acute Kidney Injury Flashcards

(60 cards)

1
Q

Define acute kidney injury.

A

A rapidly progressive, sudden decline in kidney function that may be reversible

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What would a GFR be for someone with AKI?

A

<90ml/min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What would urine output look like for someone with AKI?

A

<30 ml/hr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What would BUN look like for someone with AKI?

A

> 20 mg/dL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What would creatinine look like for someone with AKI?

A

> 1.2 mg/dL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How fast does AKI occur?

A

It usually occurs within hours of onset of the problem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are four labs that we can use to determine if someone is having an AKI?

A

GFR, urine output, BUN, creatinine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What urine output is normal for 24 hours?

A

Greater than 400 mLs in 24 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the medical term for decreased urine output?

A

oliguria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the normal BUN range?

A

10-20

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the normal range for creatinine?

A

0.5-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

AKI encompasses the entire scope of the syndrome, which means…

A

It can range from slight deterioration in kidney function to severe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is AKI characterized by?

A

Rapid loss in kidney function, within hours to days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Does someone with AKI always have decreased urine output?

A

No, it can be with or without urine output

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Although AKI is potentially reversible, it has a very high __ __.

A

mortality rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

A person who suffers an AKI is typically suffering from other…

A

life threatening conditions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are three typical precursors to an AKI?

A

Severe, prolonged hypotension, hypovolemia, or exposure to a nephrotoxic agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Why does hypotension and/or hypovolemia result in an AKI?

A

Decreased perfusion to the kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Where do most AKI occur?

A

Prerenal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is a prerenal cause of AKI?

A

It originates in the intravascular system, before the kidneys, such as decreased cardiac output

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the most common cause of intrarenal AKI?

A

Acute tubular necrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is acute tubular necrosis?

A

Damage to the tubule cells which results in the kidneys not being able to filter the blood, a build up of wastes occurs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What causes acute tubular necrosis?

A

Ischemia of the kidneys or damage from a toxic substance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Hypokalemia would cause which type of AKI?

A

Prerenal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is an example of a post renal cause of AKI?
BPH, a back up of urine causes AKI
26
What are the three different phases of AKI?
Oliguric, diuretic, and recovery phase
27
How long does it take for someone to recover from AKI?
It can last 1-3 weeks
28
Someone with an AKI will develop __ __ excess
Fluid volume excess
29
Because an AKI can lead to fluid volume excess, what will this result in?
Hyponatremia
30
A patient whose kidneys are not working build up wastes in the blood which leads to __ __
Metabolic acidosis
31
What is a neurological sign of AKI?
Altered LOC
32
Is someone with AKI/CKD hypokalemic or hyperkalemic?
Hyperkalemic
33
What is the primary treatment in AKI?
Undo what is causing the injury and correct fluid and electrolyte imbalances
34
What are the manifestations of acute kidney injury?
Hyperkalemia Hyponatremia (dilutional) Fluid volume excess Metabolic acidosis Altered LOC Decreased urine output
35
What are four additional treatments for AKI?
Manage BP Prevent/Treat infections Maintain Nutrition Avoid nephrotoxic drugs
36
Someone with AKI may have __ restrictions
fluid
37
What orders might someone with an AKI have?
Fluid restrictions Daily weights Diuretics
38
Dietary restriction of potassium is used for what?
Prevention of recurrent hyperkalemia, not acutre hyperkalemia treatment
39
What are three GI drugs that can be used to lower serum potassium?
Patiromer (Veltassa) Sodium zirconium cyclosilicate (Lokelma) Sodium polystyrene sulfonate (Kayexalate)
40
Sodium polystyrene sulfonate can be given __ or __
Po or enema
41
Kayexalate can be given __ or __
PO or enema
42
What is the brand name of sodium polystyrene sulfonate?
Kayexalate
43
What is the generic name of Kayexalate?
sodium polystyrene sulfonate
44
What is the brand name of patiromer?
Veltassa
45
What is the generic name of Veltassa?
Patiromer
46
What is the brand name of sodium zirconium cyclosilicate?
Lokelma
47
What is the generic name of Lokelma?
sodium zirconium cyclosilicate
48
What type of drug is lokelma, veltassa, and kayexalate?
Potassium binders in the GI tract, cation exchange resins
49
Kayexalate should not be used for...
emergency, life threatening hyperkalemia
50
What is a contraindication to GI potassium binders?
Paralytic ileus because we count on peristalsis to move the potassium out of the body
51
What is an intravenous medication that can be given when someone is hyperkalemic, but it doesn't actually lower serum potassium?
Calcium gluconate
52
How does calcium gluconate IV work?
Calcium increases the threshold potential, thus restoring the normal gradient between threshold potential and resting membrane potential, which is abnormally elevated in hyperkalemia.
53
What is a combination that can be given IV to correct hyperkalemia?
Insulin and glucose
54
How does insulin and glucose help to correct hyperkalemia?
It temporarily shifts potassium back into the cells and out of the blood
55
What base can be given IV to correct hyperkalemia?
Sodium bicarbonate
56
How does sodium bicarbonate correct hyperkalemia?
It corrects acidosis and forces K back into the cells
57
What is the disadvantage of Calcium gluconate, Insulin, and Bicarb for hyperkalemia correction?
They are all temporary, only buys you some time
58
Potassium is a major __ __ of the body
intracellular cation
59
Cations have a __ charge
positive
60
What is the most effective way to remove potassium from the body?
Hemodialysis