Ageing, Alzheimer's, MS and Parkinson's - Alzheimers Flashcards
(10 cards)
What does Donepezil do?
It inhibits acetylcholinesterase to raise acetylcholine levels but has limited benefit and side effects.
Why have amyloid-beta targeting drugs failed?
Because amyloid-beta is now considered a symptom rather than the cause of Alzheimer’s.
How is acetylcholine produced?
From mitochondrial acetyl-CoA and dietary choline; supported by diet, BDNF, and vagus nerve stimulation.
Why is acetylcholine important in Alzheimer’s?
It supports memory, mood, mitochondrial health, and is anti-inflammatory.
How does aluminium affect the brain?
It accumulates in neurons, disrupts ATP, and is implicated in Alzheimer’s pathology.
What chelates aluminium effectively?
Silica-rich water, cilantro, and chlorella.
Why is Alzheimer’s called Type 3 diabetes?
Due to its strong links to insulin resistance and obesity-induced inflammation.
How does obesity increase Alzheimer’s risk?
By reducing vagus nerve activity, BDNF, acetylcholine, and increasing inflammation.
What foods support brain health according to Dr. Perlmutter?
Low GI vegetables, healthy fats, fatty fish, whole unprocessed foods, and water.
What is the MIND diet?
A hybrid of Mediterranean and DASH diets designed to protect against Alzheimer’s by promoting brain-healthy foods.
