Ageing, Alzheimer's, MS and Parkinson's - exercise Flashcards
(10 cards)
How does exercise impact ageing?
Exercise mitigates all the hallmarks of ageing and extends lifespan.
What systems benefit from regular exercise?
Brain, cardiovascular, lung, muscle, metabolic, and body composition.
How does exercise influence antioxidant production?
Through hormesis and Nrf2 activation, exercise increases endogenous antioxidant enzymes.
What is PGC1-alpha and its role in exercise?
PGC1-alpha is a protein that stimulates mitochondrial biogenesis, helping create new mitochondria.
How does exercise support brain health?
It enhances mitochondrial function and reduces oxidative stress, supporting cognitive performance.
What type of stress does exercise induce beneficially?
Mild oxidative stress that triggers protective cellular mechanisms.
What is mitochondrial biogenesis?
The process of creating new mitochondria, stimulated by exercise and necessary for energy production.
How does exercise relate to Nrf2?
Exercise activates Nrf2, leading to the upregulation of genes for detoxification and antioxidant protection.
What are long-term benefits of exercise on inflammation?
Exercise lowers chronic inflammation and improves immune regulation.
Why is exercise considered anti-ageing?
Because it activates longevity pathways, supports mitochondrial health, and reduces age-related decline.
