Anti-coagulant Drugs Flashcards Preview

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Flashcards in Anti-coagulant Drugs Deck (21)
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1
Q

Mechanism of action of warfarin

A

Inhibit vitamin K epoxide reductase, reduces recycling of vitamin K, reduces synthesis of prothrombin and factor VII, IX, and X

2
Q

ADRs of warfarin

A

Bruising, Intracranial haemorrhage, GI bleeding

In pregnancy: Teratogenic, Intracranial haemorrage at birth

3
Q

DDIs of warfarin

A

Effected by inducers and inhibitors, Displacement by drugs bound to plasma proteins, Cephalosporins reduce Vit K production in the gut

4
Q

Treatment of warfarin overdose

A

Oral Vit K, Fresh frozen plasma, Prothrombin complex

5
Q

Monitoring of warfarin

A

INR (2 - 4.5)

6
Q

Define INR

A

Patients prothrombin time / expected prothrombin time

7
Q

Types of heparin

A

Low molecular weight, Unfractionated

8
Q

Mechanism of action of heparin

A

Activate anti-thrombin III, inhibits clotting factors

9
Q

Factor affected by low molecular weight heparin

A

Factor X

10
Q

Factors affected by unfractionated heparin

A

Factor X and Prothrombin

11
Q

Why does low molecular weight heparin not inhibit prothrombin

A

Not large enough to bind both anti-thrombin III and prothrombin

12
Q

ADRs of heparin

A

Intracranial haemorrhage, Epistaxis, GI bleeding, Osteoporosis, Autoimmune thrombocytopenia

13
Q

Treatment of heparin overdose

A

Protamine sulphate

14
Q

Monitoring of heparin

A

Activated partial thromboplastin time

15
Q

Classes of antiplatelet drugs

A

Aspirin, Dipyridamole, Platelet ADP receptor blockers, Glycoprotein receptor inhibitors

16
Q

Mechanism of action of Aspirin (Anti-platelet)

A

Inhibit COX - 1 reducing the synthesis of thromboxane

17
Q

Mechanism of action of Dipridamole

A

Inhibit phosphodiesterase reducing break down of cAMP reducing platelet aggregation

18
Q

Example of platelet ADP receptor blocker

A

Clopidogrel

19
Q

Mechanism of action of clopidogrel

A

Prevent ADP from binding to platelets reducing aggregation

20
Q

Example of glycoprotein receptor blockers

A

Abciximab

21
Q

Mechanism of action of Abciximab

A

Prevent fibrin binding to glycoprotein receptors reducing aggregation