Anti-coagulant Drugs Flashcards Preview

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Flashcards in Anti-coagulant Drugs Deck (21):
1

Mechanism of action of warfarin

Inhibit vitamin K epoxide reductase, reduces recycling of vitamin K, reduces synthesis of prothrombin and factor VII, IX, and X

2

ADRs of warfarin

Bruising, Intracranial haemorrhage, GI bleeding
In pregnancy: Teratogenic, Intracranial haemorrage at birth

3

DDIs of warfarin

Effected by inducers and inhibitors, Displacement by drugs bound to plasma proteins, Cephalosporins reduce Vit K production in the gut

4

Treatment of warfarin overdose

Oral Vit K, Fresh frozen plasma, Prothrombin complex

5

Monitoring of warfarin

INR (2 - 4.5)

6

Define INR

Patients prothrombin time / expected prothrombin time

7

Types of heparin

Low molecular weight, Unfractionated

8

Mechanism of action of heparin

Activate anti-thrombin III, inhibits clotting factors

9

Factor affected by low molecular weight heparin

Factor X

10

Factors affected by unfractionated heparin

Factor X and Prothrombin

11

Why does low molecular weight heparin not inhibit prothrombin

Not large enough to bind both anti-thrombin III and prothrombin

12

ADRs of heparin

Intracranial haemorrhage, Epistaxis, GI bleeding, Osteoporosis, Autoimmune thrombocytopenia

13

Treatment of heparin overdose

Protamine sulphate

14

Monitoring of heparin

Activated partial thromboplastin time

15

Classes of antiplatelet drugs

Aspirin, Dipyridamole, Platelet ADP receptor blockers, Glycoprotein receptor inhibitors

16

Mechanism of action of Aspirin (Anti-platelet)

Inhibit COX - 1 reducing the synthesis of thromboxane

17

Mechanism of action of Dipridamole

Inhibit phosphodiesterase reducing break down of cAMP reducing platelet aggregation

18

Example of platelet ADP receptor blocker

Clopidogrel

19

Mechanism of action of clopidogrel

Prevent ADP from binding to platelets reducing aggregation

20

Example of glycoprotein receptor blockers

Abciximab

21

Mechanism of action of Abciximab

Prevent fibrin binding to glycoprotein receptors reducing aggregation