Antidepressant Drugs Flashcards Preview

Pharmacology > Antidepressant Drugs > Flashcards

Flashcards in Antidepressant Drugs Deck (19):
1

Examples of SSRIs

Fluoxetine, Citalopram

2

Mechanism of action of SSRIs

Inhibit 5HT reuptake pump, remains in the synaptic cleft

3

ADRs of SSRIs

Nausea, Anorexia, Diarrhoea, Mania, Suicidal intentions, Extrapyramidal signs

4

Example of Tricyclic antidepressants

Amityptiline

5

Mechanism of action of Tricyclic antidepressants

Inhibit noradrenaline reuptake, remains in the synaptic cleft

6

ADRs of Tricyclic antidepressants

Sedation, Constipation, Reduced contractility, Postural hypotension, Tachycardia, Lowers seizure threshold, Reduced glandular secretion

7

Example of seretonin noradrenaline reuptake inhibitors

Venlafaxine

8

Mechanism of action of seretonin noradrenaline reuptake inhibitors

Inhibit 5HT and noradrenaline reuptake, remain in the synaptic cleft

9

ADRs of seretonin noradrenaline reuptake inhibitors

Sleep disturbances, Hypertension, Dry mouth, Hyponatraemia

10

Mechanism of action of monoamine oxidase inhibitors

Prevent MAO from breaking down 5HT and noradrenaline

11

Example of Typical antipsychotic

Haloperidol

12

Mechanism of action of Typical antipsychotics

Dopamine antagonism

13

ADRs of Typical antipsychotics

Extrapyramidal signs, Hyperprolactinaemia, Infertility, Sexual dysfunction, Tardive dyskinesia, Hyperthermia, Postural hypotension, Weight gain, Pigmentation, Long QT

14

Example of Atypical antipsychotics

Risperidone

15

Mechanism of action of Atypical antipsychotics

Antagonise dopamine and 5HT

16

ADRs of Atypical antipsychotics

Weight gain, Sedation

17

Mechanism of action of Lithium

Compete with Mg and Ca for transport or increase 5HT

18

ADRs of Lithium

Memory problems, Polyuria, Polydipsia, Tremor, Drowsiness, Weight gain, Reduced renal function, Reduced thyroid function

19

S+S of Lithium overdose

Vomiting, Diarrhoea, Tremor, Dysarthia, Cognitive impairment, Agitiation