Anti-hypertensive Drugs Flashcards Preview

Pharmacology > Anti-hypertensive Drugs > Flashcards

Flashcards in Anti-hypertensive Drugs Deck (22):
1

Examples of ACE-I

Ramipril, Lisinopril

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Mechanism of action of ACE-I

Inhibit ACE, reducing the level of angiotensin II causing reduced vasoconstriction, reduced levels of aldosterone reducing water retention

3

ADRs of ACE-I

Dry cough, First dose hypertension, Hypotension, Hyperkalaemia, Headaches, Reduced renal function

4

DDIs of ACE-I

Hypokalaemia with thiazide and loop diuretics
Hypotension with diuretics

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Examples of beta blockers

Atenolol, Bisoprolol

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Mechanism of action beta blockers (hypertension)

Reduce SNS, reduce contractility and heart rate, reduces cardiac output

7

ADRs of beta blockers

Reduced exercise tolerance, Bronchospasm, Bradycardia

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DDIs of beta blockers

Bradycardia with cardiac glycosides, Reduced effectiveness with beta agonists

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Types of Ca channel blockers

Dihydropyridines, Phenylalkylamines, Benzothiazepines

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Example of dihydropyridine

Amilodipine

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Example of phenylalkylamine

Verapamil

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Example of benzothiaepine

Diltiazam

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Mechanism of action of dihydropyridines

Reduce Ca influx into vascular smooth muscle causing vasodilation

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Mechanism of action of phenylalkylamines and benzothiazepines

Slow conduction through the SA and AV nodes

15

ADRs of dihydropyridines

Tachycardia, Palpitations, Flushing, Sweating, Oedema, Headaches

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ADRs of phenylalkylamines

Constipation, Bradycardia, Reduced contractility

17

ADRs of benzothiazepines

Bradycardia, Reduced contracility

18

Example of cardiac glycosides

Digoxin

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Mechanism of action of cardiac glycosides

Inhibit Na/K ATPase reducing Na conc, reverses the NCX reducing intracellular Ca reducing contractility

20

ADRs of digoxin

Nausea, Vomiting, Dizziness, Agitation, Depression, Convulsions, Psychosis, Arrhythmia

21

Management pathway for hypertension

1. 55 or black = Ca channel blocker
2. Add either ACE-I or Ca channel blocker
3. Add thiazide diuretic
4. Increase diuretic or add beta blocker

22

Management for heart failure

Beta blockers, ACE-I, Cardiac glycosides, Thiazide diuretics, Aldosterone antagonists