Chemotherapy Drugs Flashcards Preview

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Flashcards in Chemotherapy Drugs Deck (13)
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1
Q

Classes of chemotherapy drugs

A

Antimetabolites, Alkylating agents, Intercalating agents, Mitotic inhibitors

2
Q

Examples of antimetabolites (Chemotherapy)

A

5 Fluorouracil, Methotrexate

3
Q

Mechanism of action of antimetabolites (Chemotherapy)

A

Inhibit purine and pyramidine synthesis, Preventing DNA synthesis

4
Q

Example of alkylating agents

A

Cisplatin

5
Q

Mechanism of action of alkylating agents

A

Form covalent bonds between DNA strands preventing DNA replication

6
Q

Examples of mitotic inhibitors

A

Taxanes, Vinca alkaloids

7
Q

Mechanism of action of Taxanes

A

Inhibit spindle recycling

8
Q

Mechanism of action of Vinca alkaloids

A

Prevent spindle formation

9
Q

ADRs of chemotherapy

A

Alopecia, Mucositis, Vomiting, Skin toxicity, Lung fibrosis, Cardiac toxicity, Myelosuppression, Diarrhoea, Renal failure, Myalgia

10
Q

ADR of Cisplatin

A

Peripheral neuropathy

11
Q

ADRs of mitotic inhibitors

A

Glove and stocking neuropathy

12
Q

Monitoring during chemotherapy

A

ECGs, LFTs, Spirometry, Creatinine, Evoked neural response, Radiological imaging, Tumour markers

13
Q

Mechanisms of chemotherapy resistance

A

Upregulate multidrug resistance protein, Down regulate uptake proteins, Up regulate inhibiting enzymes, Up regulate DNA repair enzymes