Chemotherapy Drugs Flashcards Preview

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Flashcards in Chemotherapy Drugs Deck (13):
1

Classes of chemotherapy drugs

Antimetabolites, Alkylating agents, Intercalating agents, Mitotic inhibitors

2

Examples of antimetabolites (Chemotherapy)

5 Fluorouracil, Methotrexate

3

Mechanism of action of antimetabolites (Chemotherapy)

Inhibit purine and pyramidine synthesis, Preventing DNA synthesis

4

Example of alkylating agents

Cisplatin

5

Mechanism of action of alkylating agents

Form covalent bonds between DNA strands preventing DNA replication

6

Examples of mitotic inhibitors

Taxanes, Vinca alkaloids

7

Mechanism of action of Taxanes

Inhibit spindle recycling

8

Mechanism of action of Vinca alkaloids

Prevent spindle formation

9

ADRs of chemotherapy

Alopecia, Mucositis, Vomiting, Skin toxicity, Lung fibrosis, Cardiac toxicity, Myelosuppression, Diarrhoea, Renal failure, Myalgia

10

ADR of Cisplatin

Peripheral neuropathy

11

ADRs of mitotic inhibitors

Glove and stocking neuropathy

12

Monitoring during chemotherapy

ECGs, LFTs, Spirometry, Creatinine, Evoked neural response, Radiological imaging, Tumour markers

13

Mechanisms of chemotherapy resistance

Upregulate multidrug resistance protein, Down regulate uptake proteins, Up regulate inhibiting enzymes, Up regulate DNA repair enzymes