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Flashcards in General Pharmacology Deck (28):
1

Calculation for oral bioavailability

Plasma conc / dose given

2

Factors affecting oral bioavailability

Lipophilicity, Molecule size, First pass metabolism

3

Calculation for distribution

Dose given / plasma conc

4

Compartments the drug is in with a Vd < 0.2

Plasma

5

Compartments the drug is in with a Vd between 0.2 and 0.7

ECF

6

Compartments the drug is in with a Vd > 0.7

Whole body (Fat)

7

Factors affecting volume of distribution

Lipid solubility, DDIs, Protein binding, Diseases

8

Measure of elimination

Half-life

9

Calculation for half life

0.693 x Vd / Clearance

10

Define first order kinetics

Elimination is proportional to dose

11

Define zero order kinetics

Elimination constant over time

12

Number of half lives to reach steady state

4-5

13

Calculation for loading dose

Vd x Desired conc

14

Define selectivity

Drugs ability to bind to a receptor

15

Define specificity

Drugs ability to cause a response in a receptor

16

Define affinity

How readily a drug binds to a receptor

17

Measure of affinity

Kd

18

Define Kd

Conc at which 50% of receptors are occupied

19

Define efficacy

Degree of response from a receptor generated by a drug

20

Define potency

Dose required to generate a response

21

Measure of potency

EC50

22

Define EC50

Conc at which a 50% response is generated

23

Types of ADRs

On target and off target

24

Define on target ADRs

Greater than desired effect at target site

25

Define off target ADRs

Where drug works on an undesired receptor type

26

Common CYP450 inducers

Phenytoin, Carbamezpine, Barbituates, Rifampacin, Alcoholism, St John's wort

27

Common CYP450 inhibitors

Omeprazole, Disulfaram, Erythromycin, Valproate, Isoniazid, Ciprofloxacin, Ethanol, Sulphpnylamide

28

Common drugs bound to plasma protein

Sulphonylureas, Phenytoin, Valproate, Carbamezepine, NSAIDs, Warafrin, Glitazones, Heparin