Lipid Lowering Drugs Flashcards Preview

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Flashcards in Lipid Lowering Drugs Deck (15):
1

Examples of statins

Simvostatin, Atorvastatin

2

Mechanism of action of statins

Inhibit HMG~CoA reductase in the liver, Cause reduced cholesterol synthesis, Increases LDL receptors on liver

3

ADRs of statins

Myopathy, Rhambdomyolysis, Elevated hepatic enzymes

4

Approx Vd of statins

250 - 400L

5

Half-life of simvostatin

4hrs

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Half-life of atorvastatin

20hrs

7

DDIs of statins

Myopathy with fibrates, Subject to inducers and inhibitors

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Monitoring with statins

LFTs

9

Examples of fibrates

Bezofibrate, Ciprofibrate

10

Mechanism of action of fibrates

Activate PPAR alpha receptors, Causes lipid uptake and lipoysis

11

ADRs of fibrates

GI upset, Myositis, Gall stones

12

DDIs of fibrates

Increased risk of myopathy with statins

13

Example of cholesterol uptake inhibitors

Ezetimibe

14

Mechanism of action of cholesterol uptake inhibitors

Block cholesterol transport proteins in the intestines reducing uptake, Increases LDL receptors on liver

15

ADRs of cholesterol uptake inhibitors

Headaches, Abdo pain, Diarrhoea