Lipid Lowering Drugs Flashcards Preview

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Flashcards in Lipid Lowering Drugs Deck (15)
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1
Q

Examples of statins

A

Simvostatin, Atorvastatin

2
Q

Mechanism of action of statins

A

Inhibit HMG~CoA reductase in the liver, Cause reduced cholesterol synthesis, Increases LDL receptors on liver

3
Q

ADRs of statins

A

Myopathy, Rhambdomyolysis, Elevated hepatic enzymes

4
Q

Approx Vd of statins

A

250 - 400L

5
Q

Half-life of simvostatin

A

4hrs

6
Q

Half-life of atorvastatin

A

20hrs

7
Q

DDIs of statins

A

Myopathy with fibrates, Subject to inducers and inhibitors

8
Q

Monitoring with statins

A

LFTs

9
Q

Examples of fibrates

A

Bezofibrate, Ciprofibrate

10
Q

Mechanism of action of fibrates

A

Activate PPAR alpha receptors, Causes lipid uptake and lipoysis

11
Q

ADRs of fibrates

A

GI upset, Myositis, Gall stones

12
Q

DDIs of fibrates

A

Increased risk of myopathy with statins

13
Q

Example of cholesterol uptake inhibitors

A

Ezetimibe

14
Q

Mechanism of action of cholesterol uptake inhibitors

A

Block cholesterol transport proteins in the intestines reducing uptake, Increases LDL receptors on liver

15
Q

ADRs of cholesterol uptake inhibitors

A

Headaches, Abdo pain, Diarrhoea