Asthma Drugs Flashcards Preview

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Flashcards in Asthma Drugs Deck (16)
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1
Q

Examples of Beta agonists

A

Salbutamol, Salmeterol

2
Q

Mechanism of action of beta agonists

A

Activate Beta receptors, increasing intracellular Ca, causing bronchodilation

3
Q

ADRs of beta agonists

A

Tachycardia, Dysrhythmia, Palpitations, Tremor

4
Q

Half-life of salbutamol

A

4hrs

5
Q

Half-life of salmeterol

A

12hrs

6
Q

DDIs of beta agonists

A

Not effective if given with beta bockers

7
Q

Mechanism of action of inhaled corticosteroids

A

Down regulate interleukin 1 and 6

8
Q

ADRs of inhaled corticosteroids

A

Sore throat, Oral thrush

9
Q

Examples of methylaxines

A

Theophyline, Aminophylline

10
Q

Mechanism of action of methylaxines

A

Antagonise adenosine receptors

11
Q

ADRs of methylaxines

A

Nausea, Vomiting, Reflux, Arrhythmia, Seizures

12
Q

DDIs of methylaxines

A

Effected by inducers and inhibitors

13
Q

Examples of anticholinergics (asthma)

A

Ipratropium bromide, Tiotropium bromide

14
Q

Mechanism of action of anticholinergics (asthma)

A

Antagonise ACh receptors reducing bronchoconstriction and mucus secretion

15
Q

ADRs of anticholinergics

A

Dry mouth, Urine retention, Glaucoma

16
Q

Management pathway for asthma

A
  1. SABA
  2. Add inhaled steroid
  3. Add LABA
  4. Increase steroids
  5. Add anticholinergic, Methylaxine, or leukotriene receptor blocker
    6 Add oral steroids