Non-steroidal Anti-inflammatory Drugs Flashcards Preview

Pharmacology > Non-steroidal Anti-inflammatory Drugs > Flashcards

Flashcards in Non-steroidal Anti-inflammatory Drugs Deck (12):
1

Examples of NSAIDs

Ibuprofen, Naproxen

2

Mechanism of action of NSAIDs

Inhibit COX 2 preventing the conversion of arachidonic acid to prostaglandins

3

Action of EP1 receptors

Cause hyperalgesia

4

Action of EP2 receptors

Cause vasodilation

5

Action of EP3 receptors

Cause fever

6

ADRs of NSAIDs

Bronchial asthma, Peptic disease, Reduced GFR, Reduced clotting, Reye's syndrome, Stevens Johnson syndrome

7

Describe Reye's syndrome

Rash, Encephalopaty, and fatty liver caused by giving minors aspirin

8

Describe Stevens Johnson syndrome

Hepatic damage, and inflammation of mucosal membranes

9

Describe how NSAIDs are made selective for COX 2

Made bigger, COX 1 has a narrower active site

10

DDIs of NSAIDs

Displacement of plasma protein bound drugs, Bleeding with anti-coagulants

11

Mechanism of action of Paracetamol

Inhibition of COX enzymes in the CNS

12

ADRs of Paracetamol

Hepatic damage, Stevens Johnson syndrome