Non-steroidal Anti-inflammatory Drugs Flashcards Preview

Pharmacology > Non-steroidal Anti-inflammatory Drugs > Flashcards

Flashcards in Non-steroidal Anti-inflammatory Drugs Deck (12)
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1
Q

Examples of NSAIDs

A

Ibuprofen, Naproxen

2
Q

Mechanism of action of NSAIDs

A

Inhibit COX 2 preventing the conversion of arachidonic acid to prostaglandins

3
Q

Action of EP1 receptors

A

Cause hyperalgesia

4
Q

Action of EP2 receptors

A

Cause vasodilation

5
Q

Action of EP3 receptors

A

Cause fever

6
Q

ADRs of NSAIDs

A

Bronchial asthma, Peptic disease, Reduced GFR, Reduced clotting, Reye’s syndrome, Stevens Johnson syndrome

7
Q

Describe Reye’s syndrome

A

Rash, Encephalopaty, and fatty liver caused by giving minors aspirin

8
Q

Describe Stevens Johnson syndrome

A

Hepatic damage, and inflammation of mucosal membranes

9
Q

Describe how NSAIDs are made selective for COX 2

A

Made bigger, COX 1 has a narrower active site

10
Q

DDIs of NSAIDs

A

Displacement of plasma protein bound drugs, Bleeding with anti-coagulants

11
Q

Mechanism of action of Paracetamol

A

Inhibition of COX enzymes in the CNS

12
Q

ADRs of Paracetamol

A

Hepatic damage, Stevens Johnson syndrome