Immunosuppressant Drugs Flashcards Preview

Pharmacology > Immunosuppressant Drugs > Flashcards

Flashcards in Immunosuppressant Drugs Deck (23):
1

Examples of corticosteroids

Prednisone, Hydrocortisone

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Mechanism of action of corticosteroids (Immunosuppressants)

Reduce production of interleukin 1 and 6, inhibit the action of T cells

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ADRs of corticosteroids

Weight gain, Glucose intolerance, Insomnia, Hypertension, Psychosis, Gastritis, Pancreatitis, Osteoporosis

4

Monitoring of corticosteroids

Monitor inflammatory markers

5

Mechanism of action of Azathioprine

Forms 6-MP which inhibit purine synthesis, reduces DNA synthesis, reduces lymphocyte number

6

ADRs of Azathioprine

Myelosuppression, Lymphoma, Infection, Hepatitis

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Monitoring of Azathioprine treatment

LFTs and FBCs

8

Test before Azathioprine treatment

Test for TPMT levels

9

Mechanism of action of methotrexate (Immunosuppressant)

Increased adenosine levels reducing T cell activity

10

ADRs of methotrexate

Mucositis, Myelosuppression, Hepatitis, Cirrhosis, Infection, Pneumonitis, Teratogenesis

11

Monitoring during methotrexate treatment

FBCs, LFTs, U+Es, CXR

12

Mechanism of action of Sulphasalazine

Salicylate in colon reducing cytokines, Sulphpyridine in circulation reduces interleukin 2 production in T cells

13

ADRs of Sulphsalazine

Myelosuppression, Hepatitis, Nausea, Vomiting, Abdo pain

14

Mechanism of action of Cyclophosphamide

Metabolites act as alkylating agents inhibiting DNA synthesis, reduces lymphocyte number

15

ADRs of Cyclophosphamide

Bladder cancer, Leukaemia, Infertility

16

DDIs of Cyclophosphamide

Effected by inducers and inhibitors

17

Mechanism of action of Mycophenolate Mofetil

Inhibits guanine synthesis, reducing lymphocyte number

18

ADRs of Mycophenolate Mofetil

Nausea, Vomiting, Leukopenia, Neutropenia, Myelosuppression, Infection

19

Examples of Calcineurin inhibitors

Ciclosporin, Tacrolimus

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Mechanism of action of Calcineurin inhibitors

Inhibit calcineurin preventing the transcription of interleukin 2

21

ADRs of Calcineurin inhibitors

Nephrotoxicity, Hypertension

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DDIs of Calcineurin inhibitors

Effected by inducers and inhibitors

23

Monitoring of Calcineurin inhibitor treatment

BP, eGFR