Diabetic Drugs Flashcards Preview

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Flashcards in Diabetic Drugs Deck (22):
1

Example of Biguanide

Metformin

2

Mechanism of action of Metformin

Increase insulin sensitivity in the skeletal muscle and adipose, Decrease hepatic gluconeogenesis

3

ADRs of metformin

Nausea, Vomiting, Lactic acidosis, B12 deficiency

4

Examples of thiazonlidinediones (glitazones)

Piaglitozone, Rosiglitazone

5

Mechanism of action of thiazonlidinediones (glitazones)

Activate PPAR gamma receptors reducing gluconeogenesis and increasing glucose uptake

6

ADRs of thiazonlidinediones (glitazones)

Weight gain, Heart failure, Oedema

7

DDIs of thiazonlidinediones (glitazones)

Displacement from plasma proteins

8

Half-life of thiazonlidinediones (glitazones)

7hrs, metabolites active for 150hrs

9

Examples of sulphonylureas

Tolbutamide, Glibenclamide

10

Mechanism of action of sulphonylureas

Antagonise the ATP dependent K channels on beta cells, cause depolarisation opening VOCC causing insulin release

11

ADRs of sulphonylureas

Nausea, Weight gain, Vomiting, Hypoglycaemia

12

DDIs of sulphonylureas

Displacement from plasma proteins

13

Mechanism of action of gliptins

Mimic GLP1 - increase insulin secretion, decrease glucagon secretion, decrease gluconeogenesis, increase glucose uptake by muscles

14

ADRs of gliptins

GI upset

15

Mechanism of action of alpha glucosidase inhibitors

Inhibit alpha glucosidase preventing the breakdown of dietary carbohydrates to glucose

16

ADRs of alpha glucosidase inhibitors

Flatulence, Loose stool, Abdo pain

17

Mechanism of SGLT2 inhibitors

Inhibit SGLT2 reducing reabsorption of glucose in the nephron

18

ADRs of SGLT2 inhibitors

UTIs, Polyuria, Hypoglycaemia

19

Two types of insulin regimin

Basal bolus and pre-mixed

20

Describe basal bolus regimin

Long acting given as a base, short acting given with meals

21

Describe pre-mixed regimin

Combination of long and short acting given twice daily

22

Steps in managing diabetes

1. Life style changes
2. Metformin
3. Add sulphonylurea
4. Add glitazone, gliptin,or SGLT inhibitor
5. Begin insulin