Anti-epileptic Drugs Flashcards Preview

Pharmacology > Anti-epileptic Drugs > Flashcards

Flashcards in Anti-epileptic Drugs Deck (18):
1

Examples of voltage gated sodium channel blockers

Carbamezepine, Lamotrigine, Phenytoin

2

Mechanism of action of voltage gated sodium channel blockers

Block voltage gated sodium channels slowing the rate of firing of neurones

3

ADRs of carbamezepine

Dizziness, Rashes, Ataxia, Tingling, GI upset, Hyponatremia, Myelosuppression

4

ADRs of Phenytoin

Dizziness, Rashes, Ataxia, Headache, Nystagmus, Gingival, Hyperplasia

5

ADRs of Lamotrigine

Dizziness, Rashes, Nausea

6

DDIs of carbamezepine

Displacement of plasma protein bound drugs, Reduced effect with anti-depressants, Reduced effectiveness with Warfarin and steroids

7

DDIs of Phenytoin

Displacement of plasma protein bound drugs

8

DDIs of Lamotrigine

Displacement of plasma protein bound drugs, Reduced levels with OCP

9

Monitoring with phenytoin

Plasma levels monitored with a saliva test

10

Examples of GABA mediated inhibitors

Valproate, Benzodiazepines

11

Examples of benzodiazepines

Lorazepam, Diazepam

12

ADRs of Valproate

Ataxia, Weight gain, Liver failure
In pregnancy: Neural tube defects, reduced Vit K

13

ADRs of Benzodiazepines

Sedation, Confusion, Aggression, Tolerance, Resp depression, CNS depression, Rapid withdrawal causes seizures

14

DDIs of Valproate

Reduced efficacy with anti-depressants

15

Treatment of Benzodiazepine overdose

Flumazenil

16

Management of general seizures

1. Valproate
2. Lamotrigine

17

Management of partial seizures

Carbamezepine

18

Management of status epilepticus

After 5 min give lorazepam
After 10 min give second dose of lorazepam
After 15 min give IV phenytoin
After 30 min paraylise and ventilate