Antiarrthymics Flashcards Preview

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Flashcards in Antiarrthymics Deck (22):
1

Class I works how

"No Bad boy Keeps Clean"

Na channel blockers; phase 0

*increase in effective refractive period
*all these phases referring to ventricular

2

Class II works how

Beta blocker; phase 4

3

Class III works how

K channel blocker; phase 3

*increase in ERP, prolongs the AP duration

4

Class IV works how

Ca channel blocker; phase 0

* increase in effective refractive period

5

Class 1A examples (3)

"Double Quarter Pounder"

1. Disopyramide
2. Quinidine
3. Procainamide

6

procainamide used for what? main tox?

WPW; drug induced SLE

("SHIPP")

7

3 AEs of quinidine

1. cinchonism (HA, dizziness, tinnitus)
2. thrombocytopenia
3. ↑ QT (torsades)

8

3 IB examples (prob most used)

("Mayo, Lettuce, Tomato")

1. Mexilitine
2. Lidocaine
3. Tocainide

9

what are three main uses for lidocaine

1. acute ventricular tachycardia
2. digitalis-induced arrythmia
3. tachcardia post-MI

*1B are best post MI !!--> preferentially affect ischemic ventricular tissue

10

2 class 1C examples

(" Fries Please")

1. Flecainide
2. Propafenone

11

What 2 instances are class IC absolutely contraindicated

1. structural heart dz
2. post-MI

12

main use of 1C

LAST RESORT in refractory tachyarrhythmias

13

main uses of class II (beta blocker) as anti arrhythmics (2)

slowing ventricular rate during:
1. atrial fibrillation
2. atrial flutter

*also v-tach and SVT

14

Which beta blocker is contraindicated in Prinzmetal/s angina

propanolol --> can exacerbate angina

15

4 examples of class III

("AIDS")

1. Amiodarone
2. Ibutilide
3. Dofetilide
4. Sotalol

*also Bretylium

16

main AE with all class III?

Torsades--> all prolong the QT

17

5 main AEs of amiodarone

1. Pulmonary fibrosis
2. Hepatotoxicity
3. Hypo/ hyperthyroidism (is 40% iodine by weight)
4. Photosensitivity
5. Blue/ grey skin

*also risk of bradycardia or heart block or CHF; this is what they are used for though--> slow heart down
*amiodarone has class I, II, III, and IV effcts b/c it alters the lipid membrane

18

2 examples of Class IV

Verapamil and diltiazem--> these are the non-DHP CCBs, which have effects on the heart

19

main use of class III

used when others fail; rhythm control in a-fib; amiodarone used in WPW

20

what is a main use for Class IV

prevention of nodal arrhythmias (SVT)

21

5 AE of non-DHP CCBs?

1. constipation
2. flushing
3. edema
4. CV (CHF, heart block, sinus node depression)
5. Torsades

22

What AEs do prob ALL antiarrhythmics share

torsades, CHF, heart block, bradycardia--> they are all used to slow heart function so it makes sense

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