Flashcards in Antiarrthymics Deck (22)
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1
Class I works how
"No Bad boy Keeps Clean"
Na channel blockers; phase 0
*increase in effective refractive period
*all these phases referring to ventricular
2
Class II works how
Beta blocker; phase 4
3
Class III works how
K channel blocker; phase 3
*increase in ERP, prolongs the AP duration
4
Class IV works how
Ca channel blocker; phase 0
* increase in effective refractive period
5
Class 1A examples (3)
"Double Quarter Pounder"
1. Disopyramide
2. Quinidine
3. Procainamide
6
procainamide used for what? main tox?
WPW; drug induced SLE
("SHIPP")
7
3 AEs of quinidine
1. cinchonism (HA, dizziness, tinnitus)
2. thrombocytopenia
3. ↑ QT (torsades)
8
3 IB examples (prob most used)
("Mayo, Lettuce, Tomato")
1. Mexilitine
2. Lidocaine
3. Tocainide
9
what are three main uses for lidocaine
1. acute ventricular tachycardia
2. digitalis-induced arrythmia
3. tachcardia post-MI
*1B are best post MI !!--> preferentially affect ischemic ventricular tissue
10
2 class 1C examples
(" Fries Please")
1. Flecainide
2. Propafenone
11
What 2 instances are class IC absolutely contraindicated
1. structural heart dz
2. post-MI
12
main use of 1C
LAST RESORT in refractory tachyarrhythmias
13
main uses of class II (beta blocker) as anti arrhythmics (2)
slowing ventricular rate during:
1. atrial fibrillation
2. atrial flutter
*also v-tach and SVT
14
Which beta blocker is contraindicated in Prinzmetal/s angina
propanolol --> can exacerbate angina
15
4 examples of class III
("AIDS")
1. Amiodarone
2. Ibutilide
3. Dofetilide
4. Sotalol
*also Bretylium
16
main AE with all class III?
Torsades--> all prolong the QT
17
5 main AEs of amiodarone
1. Pulmonary fibrosis
2. Hepatotoxicity
3. Hypo/ hyperthyroidism (is 40% iodine by weight)
4. Photosensitivity
5. Blue/ grey skin
*also risk of bradycardia or heart block or CHF; this is what they are used for though--> slow heart down
*amiodarone has class I, II, III, and IV effcts b/c it alters the lipid membrane
18
2 examples of Class IV
Verapamil and diltiazem--> these are the non-DHP CCBs, which have effects on the heart
19
main use of class III
used when others fail; rhythm control in a-fib; amiodarone used in WPW
20
what is a main use for Class IV
prevention of nodal arrhythmias (SVT)
21
5 AE of non-DHP CCBs?
1. constipation
2. flushing
3. edema
4. CV (CHF, heart block, sinus node depression)
5. Torsades
22
