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Flashcards in Sleep Deck (21):
1

EEG wave when awake and alert

Beta

2

EEG wave when awake, but eyes closed, relaxed

Alpha

3

EEG wave during N1 stage of sleep

Theta

4

EEG wave during Stage N2 sleep

Sleep spindles and K complexes

5

Stage N3 EEG wave

Delta (lowest frequency, highest amplitude)

6

EEG wave during REM sleep

Beta

7

When does bruxism occur

Stage N2; is grinding teeth

8

What is the deepest non-REM sleep

N3; 25% of sleep time in young adults

9

longest phase of sleep (most time)

N2

10

When do slepwalking, night terrors, and bedwetting occur (phase)

N3

11

When does dreaming occur?

REM

*also boners, loss of motor tone

12

Extraocular movements during REM due to activity of what

Paramedian pontine reticular formation (PPRF)

13

Principal NT in REM sleep? What NT reduces REM sleep?

ACh is primary; NE reduces

14

What two drugs shorten N3 sleep?

1. Imiprimine
2. Benzos

15

What is the cause of cataplexy in narcoleptic pts?

They immediately go into REM sleep, so get muscle paralysis and fall where they stand

16

What common drug for insomnia should be avoided in the elderly

Antihistamines

17

What should be done before starting a pt on a TCA for insomnia?

Get EKG; risk of arrhythmias

18

Which sleep med can be used long-term per FDA

Eszoplicone (lunesta)

19

Difference between Zolpidem and Ramelteon MOA?

Zolpidem--> acts as benzo receptor, so rebound insomnia when withdrawn
Ramelteon--> works at melatonin receptor (non-addictive); but avoid w/ hepatic insufficiency

20

1st line tx for narcolepsy

modafinil (stimulant)

21

3 options for tx of cataplexy in narcoleptics

1. Venlafaxine
2. Fluoxetine
3. Atomoxetine (mild stim.)

*antidepressant work by increasing NE and helping prevent sudden onset of REM sleep and thus cataplexy

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