Flashcards in Hypersensitivity types (4-5 star!!) Deck (26):
1
Type I
free antigen binds IgG and causes histamin, bradykinin release= wheal and flare reaction
2
Type II
antibody mediated cytotoxicity--> IgM or IgG bind to fixed antigen on a cell and activate complement--> MAC and cell detruction
3
Type III
Immune complex--> IgG -antigen complex deposit in tissues and ativate complement there, recruiting neutrophils (C5a), incite inflammation
4
Type IV
delayed, T-cell mediated--> sensitized T-cells encounter antigen and activate macrophages= NO Ab involved
5
Acute hemolytic transfusion reaction
type II
6
Acute rheumatic fever
type II
7
Arthus reaction
type II--> is local subacute Ab-mediated HSN, usually due to injection of antigen, forming immune complexes in skin= edema, necrosis, activation of complement (occurs 4-12 hours after an immunization, etc)
8
Asthma
type I
9
contact dermatitis
type IV (nickel, cobalt allergy
10
eczema
type I
11
Graves disease
type II
12
guillan-barre syndrome
type IV
13
graft-vs-host disease
type IV
14
hashimoto thyroiditis
type IV
15
idiopathic thrombocytopenia (ITP)
type II
16
multiple sclerosis (MS)
type IV
17
myasthenia gravis
type II
18
polyarteritis nodosa
type III
19
post-streptococcal glomerulonephritis
type III
20
rheumatoid arthritis
type III
21
rhinitis
type I
22
SLE
type III
23
pernicious anemia
type II
24
erythroblastosis fetalis
type II
25
goodpasture's syndrome
type II
26