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Flashcards in Complement Deck (20):
1

what activates the classic pathway

antigen-Ab complexes (IgM or IgG)= binds complement

2

which complement protein does classic pathway activate

C1

3

what activates the alternative pathway

occurs spontaneously at a low rate, also microbial surface antigen (mannose especially)

4

what complement protein does the alternative system activate

C3

5

what activates the Lectin pathway

Mannose-binding lectin binds mannose on the surface of molecule (like microbes)

6

what two things are the most important opsonins

1. C3b
2. IgG

7

Function of C3a

anaphylaxis--> stimulates mast cells and basophils to degranulate

8

Function of C5a

neutrophil chemotaxis (also involved with anaphylaxis)

9

What complement proteins involved in creation of the MAC

C5b, C5-C9

10

which complement protein helps clear immune complexes

C3b

11

What two proteins help prevent complement activation on self cells

1. DAF
2. C1 esterase inhibitor

12

what CD is DAF

CD55

13

causes heriditary angioedema

C1 esterase inhibitor deficiency

14

recuurent pyogenic sinus and respiratory tract infections, increased susceptobility to type III HSN (glomerulonephritis)

C3 deficiency

15

recuurent Neisseria bacteremia, infections

C5-C9 deficiency (no MAC)

16

deficient in those with paroxsymal nocturnal hemoglobinuria

DAF (CD55) or GPI, which anchors DAF to the membrane

17

two CD not found on flow cytometry in paroxysmal nocturnal hemoglobinuria

1. CD55
2. CD59

18

two clinical signs of PND

1. hemosidinuria (due to chronic intravascular hemolysis)
2. thrombosis (platelets also damaged and release pro-thrombic substances)

19

hams test

for PND--> place RBS in acidic solution = lysis is + test

20

tx fr PND (3)

1. transfusion
2. warfarin
3. Eculizumab (inhibits complement)

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