Drug Metabolism Flashcards Preview

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Flashcards in Drug Metabolism Deck (14):
1

3 Phase I processes

1. oxidation
2. hydrolysis
3. reduction

2

4 Phase II proceses

"GAS"

1. glucuronidation
2. acetylation
3. sulfation
4. methylation

3

which metabolism process do elderly people lose

Phase I

4

which metabolism involves CYPs

Phase I

5

Which metabolism usually inactivates drugs

Phase II

*phase I makes drug slightly more soluble, but often drugs are still active

6

4 drugs w/ antabuse like actions

1. Metronidazole
2. Cephalosporins (some)
3. Procarbazine (CA drug)
4. 1st gen. Sulfuroneas

7

11 drugs/ drug class/ other that are P450 inhibitors

"CRACK AMIGOS" (2 more for bonus)

1. Cimetidine
2. Ritonavir (all protease inh.)
3. Amiodarone
4. Ciprofloxacin
5. Ketoconazole
6. Acute alcohol use
7. Macrolides
8. Insoniazid
9. Grapefruit juice
10. Omeprazole
11. Sulfonamides

*also gemfibrozil and quinidine

8

7 drugs that are P450 inducers

"guiness, corona, PBRS induce"

1. Griseofulvin
2. Carbamazipine
3. Phenytoin
4. Barbituates
5. Rifampin
6. St. John's wort
7. Chronic alcoholism

9

inhibits alcohol dehydrogenase

fomepizole

10

inhibits acetaldehyde dehydrogenase

disulfiram

11

what does methanol get metabolized to that is toxic

formaldehyde

12

what does ethylene glycol get metabolized to that is toxic

oxalic acid

13

methanol causes what issues (2)

acidosis and retinal damage (blindness)

14

ethlene glycol causes what 2 issues

acidosis and kidney damage

*also CNS, heart, and lung

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