Alpha and Beta Blockers Flashcards Preview

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Flashcards in Alpha and Beta Blockers Deck (19):
1

2 non-selective alpha blockers

1. phenoxybenzamine
2. phentolamine

2

phenoxybenzamine use

pheochromocytoma--> irreversible blocks, so even the high levels of catecholamines cannot overcome the blockade

3

phentolamine use

is reversible; given to pts on MAO inhibitors who eat tyramine containing foods

4

4 A1 selective drugs

1. Prazosin
2. Terazosin
3. Doxazosin
4. Tamsulosin

* all have -osin suffix!!

5

AE of A1 blockers (5)

1. 1st dose orthostatic hypotnesion
2. dizziness
3. HA
4. reflex tachcardia
5. Rebound HTN on withdrawal

6

A2 selective antagonist

Mirtazepine --> used for depression

*AE: sedation, increased serum cholesterol, increased appetite

7

5 B1 selective antagonists ("A BEAM")

1. Acebutolol (partial B agonist)
2. Betaxolol
3. Esmolol (short acting)
4. Atenolol
5. Metoprolol

8

4 nonselective B antagonists (b1 = b2) ("Please Try Not Being Picky")

1. Propanolol
2. Timolol
3. Nadolol
4. Pindolol

9

nonselective A (vasodilatory) and B antagonists

1. carvedilol
2. labetolol

10

2 partial B agonsists

1. Acebutolol (B1 selective)
2. Pindolol (B1 = B2)

*due to weak agonism, act as antagonists, b/c they block the more potent effects of NE and Epi on receptors

11

6 indications for beta blocker use

1. Angina pectoris ( decrease HR and contractility, leading to reduced 02 demand)
2. MI (decrease mortality)
3. Supraventricular tachcardia ( decrease AV node cond.; class II anti-arrhythmic)
4. HTN (decrease C.O. and renin release)
5. CHF (slows progression of chronic failure)
6. Glaucoma ( decreased secretion of aqueous humor)
7. Hyperthyroidism

12

what vessel issue are beta blockers the DOC for?

aortic dissection

13

2 drugs used for supraventricular tachycardia

1. metoprolol
2. esmolol

14

2 drugs used for glaucoma

1. timolol
2. nadolol

15

what 3 CV adverse effects can beta blockers cause

1. bradycardia
2. AV block
3. CHF

16

what 3 CNS AEs can beta blockers cause

1. sedation
2. seizures
3. sleep alterations

17

What two pt populations should beta blockers be used with extreme caution in

1. COPD/ asthmatics
2. diabetics

18

why are beta blockers potentially dangerous for diabetics (2)

1. can cause hypoglycemia (decrease glycogenolysis and glugacon release)
2, prevent sympathetic symptoms that warn of hypoglycemia

19

why should beta blockers never be given if cocaine intoxication is suspected, even if they would decrease HR?

beta blockade would leave A1 free to be stimulated unopposed by B2--> extreme elevation in BP to dangerous levels

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