Genital Embryology (4 star!) Flashcards Preview

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Flashcards in Genital Embryology (4 star!) Deck (25):
1

which structure eventually forms the adult kidney and is precursor to genitals

mesonephros

2

becomes the male genitals eventually

mesonephric (Wolffian) duct

3

becomes female genitals eventually

paramesonephric (Mullerian) duct

4

3 structures the paramesonephric (Mullerian) duct forms in female

1. uterus
2. fallopian tube
3. upper portion of vagina

5

forms lower portion of vagina

urogenital sinus

6

what gene encodes the products needed to make someone male

SRY gene (on Y chromosome)

7

what product does SRY produce needed for maleness

testis-determining factor--> produces sertoli and leydig cells

8

what hormone do sertoli cells make and function

Mullerian inhibiting factor (MIF)--> induce degeneration of paramesonephros duct

9

what structure becomes internal male genitalia? how

mesonephric (Wolffian) ducts--> via action of testosterone, made by leydig cells

10

structures formed from wolffian ducts

seminal vesicles, epididymis, ejaculatory duct. ductus deferens--> all but prostate

("SEED")

11

what causes development of male external genitalia

Dihyotestosterone--> induces urogenital sinus and genital tubercle to do so (external gen and prostate)

12

what happens with deficient MIF, but DHT is present

genetically male child w/ external male genitalia, but female and male internal genitalia

13

MIF present but 5 α reductase deficient

genetic male with internal male genitalia, but no external male genitalia until puberty

14

what happens to mesonephric duct w/o SRY

degrades sometime after 1st semester

15

genital tubercle becomes what 2 structures in female

1. glans clitoris
2. vestibular bulbs

16

genital tubercle becomes what two structures in male

1. glans penis
2. corpus cavernosum and spongiosum

17

urogenital sinus becomes what two structures in female

1. greater vestibular glands (Bartholin glands)
2. Urethral and paraurethral glands (of Skene)

18

urogenital sinus becomes what 2 structures in male

1. bulbourethral glands (of Cowper)
2. Prostate gland

19

urogenital folds become what in the female

labia minora

20

urogenital folds become what in male

ventral shaft of the penis (penile urethra)

21

labioscrotal swelling becomes what in female? male?

1. labia majora
2. scrotum

22

congenital opening on bottom of penis

hypospadias (ventral side); is more common

23

abnormal opening on top (dorsm of penis); what is this associated with

epispadias--> associated with exstrophy of bladder (ventral defect, is open to the outside world)

24

female remnants of the gubernaculum

1. ovarian ligament
2. round ligament of uterus (uterine fundis to labia majora)

25

processus vaginalis forms what in the adult male

tunica vaginalis

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