Gluconeogenesis Flashcards Preview

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Flashcards in Gluconeogenesis Deck (11):
1

what 4 enzymes are needed for gluconeogenesis

1. Pyruvate carboxylase (requires pyruvate); (pyruvate to oxaloacetate)
2. PEP carboxykinase (oxaloacetate to phosphoenol pyruvate)
3. fructose-1,6-bisphosphatase (fructose 1,6 bisphos to fructose 6 phosphate)
4. glucose 6-phosphatase (glu 6 to glucose)

2

what enzyme catalyzes the rate-limiting step in gluconeogenesis

fructose-1,6 bisphosphatase

(fructose 1,6 bisphosphonate to fructose 6 bisphosphonate)

3

what increases activity of fructose 1,6 bisphosphatase

1. ATP

4

what two things decrease the activity of fructose 1,6 bisphosphatase

1. AMP
2. fructose 2,6 bisphosphatase (indicates glycolysis is running)

5

what increases activity of pyruvate carboxylase (1st step in gluconeogenesis)

Acetyl-CoA (indicates there is energy)

6

what three tissues have glucose 6 phosphatase

1. liver
2. kidneys
3. enterocytes

*muscle cells dont have, so cant release glucose to body once it gets in

7

RBCs and BBB endothelial cell shave what glucose transporter

GLUT 1 --> allows uptake at all times

8

hepatocytes and B cells of pancreas have what glucose transporter

GLUT 2

9

skeletal muscle and adipose have what glucose transporter

GLUT 4 --> requires insulin to uptake glucose

10

neurons and placenta have what kind of glucose tansporter

GLUT 3

11

what kind of transporter takes up fructose from the gI tract

GLUT 5

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