Autoantibodies ( 4 stars!!) Flashcards Preview

Step 1 > Autoantibodies ( 4 stars!!) > Flashcards

Flashcards in Autoantibodies ( 4 stars!!) Deck (27):
1

Anti-IgG IgM Abs

Rheumtoid arthritis

2

Anti-citrullinated protein Abs (APCA)

Rheumatoid arthritis

3

Which RA Ab is more specific

ACPA

4

Anti-centromere Abs

CREST

5

Anti-DNA topoisomerase

diffuse scleroderma (also called anti-scl-70)

6

Anti-histone

Drug induced lupus

7

Antinuclear antibodies (ANA)

SLE

8

Anti-Smith

SLE

9

which SLE Ab is most specific

Anti-Smith--> ANA is a screen

10

Anti-ds DNA

Lupus nephritis

11

Anti-Jo-1

Polymyositis/Dermatomyositis

12

Anti-Ro

Sjogrens syndrome (also called Anti-SSA)

13

Anti-La

Sjogrens syndrome (also called anti-SSB)

14

Anti-U1-RNP

mixed connective tissue disease

15

anti-desmoglein

Pemphigus vulgaris

16

Anti-acetylcholine receptor

Myasthenia gravis

17

Anti-endomysial (anti-tissue transglutamase)

Celiac disease

18

Anti-gliadin

Celiac disease

19

Anti-mitochondrial

Primary Biliary cirrhosis

20

Anti-smooth muscle

autoimmune hepatitis

21

Anti-glutamate decarboxylase

type I Diabetes

22

Anti-thyrotropin receptor

Graves disease

23

Anti-thyroid peroxidase

Hashimoto thyroiditis (also called anti-TPO)

24

Anti-thyroglobulin

Hashimoto or Graves

25

Anti-basement membrane

Goodpasture's Syndrome

26

c-ANCA

Granulomtosis w/ polyangitis (Wegner's)

*this and Goodpastures affect lung and kidney

27

p-ANCA (3)

1. Pauci-immune crescenteric glomerulonephritis
2. Churg-strauss syndrome
3. Microscopic polyangiitis

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