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Flashcards in Antifungals Deck (22):
1

Are fungi prokaryotes or eukaryotes?

Eukaryotes

2

True or False: Fungal metabolism is closer to mammals than it is to bacteria.

TRUE

3

What is the MOA of azoles?

Interfere with ergosterol synthesis inhibition of 14a-demethylase

4

Are the azoles fungicidal or fungistatic?

Fungistatic

5

Which of the following has good bioavailability, Imidazoles or Triazoles?

Triazoles

6

Which of the following is less toxic, Imidazoles or Triazoles?

Triazoles

7

Why are Triazoles less toxic than Imidazoles?

Triazoles have less of an effect on mammalian metabolism than Imidazoles.

8

Can you name the 3 Imidazoles?

1. Ketoconazole

2. Clotrimazole

3. Enilconazole

9

Can you name the 4 Triazoles?

1. Itraconazole

2. Fluconazole

3. Voriconazole

4. Posaconazole

10

What are the 4 adverse effects associated with azoles?

1. Hepatitis

2. Ulcerative skin lesions (Itraconazole)

3. Teratogenic

4. Inhibition of mammalian P450 (interferes with metabolism of other drugs)

11

Which azole has the greatest likelihood of causing hepatitis, Ketoconazole, Itraconazole, or Fluconazole?

Ketoconazole

12

Is Amphotericin B fungicidal or fungistatic?

Fungistatic --> Fungicidal at high doses

13

What is the adverse effect associated with Amphotericin B?

Nephrotoxicity

14

What is 5-Flucytosine effective against?

1. Cryptococcus

2. Candida

15

Is 5-Flucytosine fungistatic or fungicidal?

Fungistatic

16

What are the 3 adverse effects associated with 5-Flucytosine?

1. Cutaneous drug eruptions in dogs

2. Myelosuppression

3. Resistance develops quickly

17

How can you avoid the quick resistance that develops to 5-Flucytosine?

Always combine 5-Flucytosine with another anti-fungal to limit resistance.

18

5-Flucytosine is an analog of what?

Pyrimidine

19

5-Flucytosine is a fluorinated pyrimidine that interferes with _____ when converted to fluorouracil.

DNA replication

20

What is the MOA of terbinafine?

Inhibition of squalene epoxidase, causing intracellular accumulation of squalene, which is toxic to cells, causing cell lysis.

21

Is terbinafine fungistatic or fungicidal?

Fungicidal

22

What adverse effect of terbinafine has been reported in the cat?

Facial pruritis