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Flashcards in Fungal Diseases Deck (25):
1

What is the organism that causes blastomycosis?

Blastomyces dermatitidis

2

With blastomyces, what are the 2 routes of infection?

1. Inhalation

2. Direction inoculation

3

How long is the incubation period of blastomycosis?

1-3 months

4

What is the "poster dog" for blastomycosis?

1. Young (2-4 yrs.)

2. Large, hunting breed

5

What are the clinical signs associated with blastomycosis?

1. Fever, anorexia, weight loss

2. Respiratory signs: cough, tachypnea, harsh lung sounds

3. Skin signs: draining lesions

4. Ocular signs: uveitis

5. Lameness: osteomyelitis

6

What abnormalities would you see on blood work with blastomycosis?

1. Low albumin

2. High globulins

3. Hypercalcemia

7

What type of diagnostics would you want to run with blastomycosis?

1. Cytology: FNA, CSF, impression smear, lung wash

2. Radiographs

3. Galactomannan

4. Culture

8

What would you see on radiographs with blastomycosis?

1. Osteolysis with periosteal reactions

2. Miliary to nodular lung pattern

9

What is the drug of choice used in treating blasto?

Itraconazole

10

What is the drug of choice in treating blasto with CNS or ocular involvement?

Fluconazole

11

What are itraconazole and fluconazole?

Triazoles

12

What would you give in addition to the itraconazole in treating blasto?

Corticosteroids

13

How long would you administer anti-fungal treatment in treating blasto?

3 - 6 months

14

What is the organism responsible for histoplasmosis?

Histoplasma capsulatum

15

Histoplasma is present in the feces of which species?

Birds and bats

16

How is histo acquired?

Inhaled

17

Where is the body does histo replicate?

Alveolar macrophages

18

What are the clinical signs of histo in cats?

1. Respiratory (40%)

2. Ocular (25%)

3. Skin involvement

4. Lymphadenopathy

19

What are the clinical signs of histo in the dog?

1. Primarily GI

2. Respiratory

3. Ocular

4. Skin

5. CNS

20

What would you see on blood work with histo?

1. Low albumin

2. High globulins

3. Increased liver enzymes (ALP, ALT, bilirubin)

4. Anemia

21

What type of diagnostics could you perform to diagnose histoplasmosis?

1. Cytology: FNS, CSF, impression smear, lung wash

2. Galactomannan

3. Imaging: Radiographs

22

What would you see on radiographs with histoplasmosis?

1. Hepato/splenomegaly

2. Osteolysis with periosteal reaction

3. Tracheobronchial lymphadenopathy

4. Variable lung patterns

23

How would you treat histoplasmosis?

Itraconazole +/- steroids

24

How would you treat a disseminated case of histoplasmosis?

Amphotericin B

25

How long would you administer anti-fungal treatment to treat histoplasmosis?

6 - 12 months