Hypothyroidism Flashcards Preview

Small Animal Internal Medicine > Hypothyroidism > Flashcards

Flashcards in Hypothyroidism Deck (25):
1

What are the clinical signs you might associate with hypothyroidism?

1. Weight gain

2. Heat seeking

3. Skin changes

4. Lethargy

5. Mental dullness

6. Exercise intolerance

2

What type of skin changes would you associate with hypothyroidism?

1. Bilateral

2. Non-puritic

3. Scaling

4. Hyperkaratosis

5. Hyperpigmentation

3

What would you see on CBC of hypothyroidism?

1. Normochromic

2. Normocytic

3. Non-regenerative anemia

4. TARGET CELLS (due to increased erythrocyte membrane cholesterol loading, associated with hypercholesterolemia)

4

What 2 major changes would you see on biochem associated with hypothyroidism?

1. Hypercholesterolemia

2. Hypertriglyceridemia

5

True or False: It is appropriate to correct all states of low thyroid concentration.

FALSE - it is inappropriate to correct states of low thyroid concentration due to non-thyroidal illnesses.

6

What is the GOLD STANDARD for measuring fT4?

Equilibrium dialysis

7

True or False: Equilibrium dialysis can distinguish animals with low TT4 due to NTI from those with hypothyroidism.

TRUE

8

A dog with primary hypothyroidism would be expected to have an increased or decreased TSH level?

Increased

9

In general, an elevated TSH is common or rare in euthyroid dogs?

RARE

10

True or False: TSH is not highly specific for primary hypothyroidism.

FALSE - TSH is HIGHLY specific for primary hypothyroidism.

11

True or False: TSH can be used alone as a screening test for hypothyroidism.

FALSE - TSH should NOT be used alone as a screening test.

12

The presence of ____ seems to be the earliest known indicator of thyroid pathology.

TgAA (anti-thyroglobulin antibodies)

13

True or False: It is appropriate to start thyroid supplementation with a low TT4.

FALSE - In order to start thyroid supplementation, there must be clinical signs consistent with hypothyroidism.

14

Which two drugs have the ability to induce true hypothyroidism?

1. Sulfa antimicrobials

2. Phenobarbital

15

True or False: Hypothyroidism is overdiagnosed.

TRUE

16

What is the drug used to treat hypothyroidism?

Levothyroxine

17

What is the dosage for Levothyroxine?

0.02 mg/kg every 12 hours

18

To monitor a patient's response to treatment with Levothyroxine, you should evaluate the dog after ___-___ weeks of supplementation.

6-8 weeks

19

True or False: Not all clinical signs of hypothyroidism are reversible.

FALSE - with treatment, ALL clinical signs of hypothyroidism are reversible.

20

When monitoring response to treatment, measure ___ and ___ 4-6 hours after administration of Levothyroxine.

1. T4

2. TSH

21

If autoantibodies are present at 4-6 hours after administration, you cannot monitor with ___. You then need to use ___.

You cannot monitor with T4. You then need to use fT4ED.

22

Post-dose (Levothyroxine) T4 should be increased, decreased, or within the reference interval?

In the upper half or above the reference interval

23

Post-dose (Levothyroxine) TSH should be increased, decreased, or within the reference interval?

Within the reference interval

24

The Levothyroxine dose should be reduced if the post-dose T4 is > ____.

> 6 ug/dL

25

What is the life expectancy of an adult dog with primary hypothyroidism?

Normal