HCM - Hypertrophic Cardiomyopathy Flashcards Preview

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Flashcards in HCM - Hypertrophic Cardiomyopathy Deck (23):
1

What is HCM a disease of?

Sarcomeres

2

With HCM, where is the specific genetic mutation located?

MyBPC (Myosin-binding protein C)

3

In cats with HCM, which is abnormal, systolic function or diastolic function?

Diastolic function

4

What type of hypertrophy develops with HCM?

Concentric hypertrophy

5

Explain how concentric hypertrophy develops with HCM...

1. Abnormal diastolic function (impaired LV myocardial relaxation)

2. Body responds by making more sarcomeres

3. Get thickening of the left ventricle

4. Concentric hypertrophy

6

What is the primary etiology of HCM?

Not enough relaxation/filling

7

What is the typical signalment of a cat with HCM?

1. Male (75%)

2. Main coon or Ragdoll

3. Middle-aged (median 6 yo)

8

What would you expect to see on echocariography of a cat with HCM?

1. LV hypertrophy

2. LV diastolic dysfunction

9

What are the 4 differentials for LV hypertrophy in the cat?

1. Hyperthyroidism

2. HCM

3. Hypertension systemically

4. Hypersomatotopism (acromegaly)

10

What causes the heart murmur in HCM?

Mitral valve regurgitation

11

Where does the fluid go in a dog with left-side CHF?

Pulmonary edema

12

Where does the fluid go in a cat with left-sided CHF?

1. Pulmonary edema

2. Pleural effusion

3. Pericardial effusion

13

Where does the fluid go in a dog with right-sided CHF?

Ascites

14

Where does the fluid go in a cat with right-sided CHF?

1. Ascites

2. Pleural effusion

3. Pericardial effusion

15

What are the 4 anti-thrombin drugs?

1. Clopidogrel

2. Heparin

3. Aspirin

4. tPA (tissue plasminogen activator)

16

What are the 3 drugs you could utilize to treat asymptomatic (stage B) HOCM?

1. Atenolol

2. Clopidogrel

3. ACE inhibitor

17

When would you use atenolol?

With LVOT obstruction

18

When would you use clopidogrel?

With moderate-severe LA enlargement

19

When would you use ACE inhibitors?

With LV/LA remodeling

20

What are the 3 drugs you could utilize to treat CHF (stage C) associated with HCM?

1. Furosemide

2. Pimobendan

3. ACE inhibitor

21

In treating CHF secondary to HOCM in the cat, what would you utilize for acute therapy (in hospital)?

1. Furosemide

2. Oxygen

3. Pimobendan

4. Sedation

5. Thoracocentesis

22

In treating CHF secondary to HOCM in the cat, what would you utilize for chronic therapy (at home)?

1. Clopidogrel

2. ACE inhibitor

3. Furosemide

4. Dietary Na restriction

5. Pimobendan

23

Which drug would you consider utilizing if pulmonary hypertension were present?

Sildenafil