Dermatophytosis Flashcards Preview

Small Animal Internal Medicine > Dermatophytosis > Flashcards

Flashcards in Dermatophytosis Deck (26):
1

Dermatophytes invade what type of tissue?

Non-viable, keratinized tissue

2

What stage of hair growth do dermatophytes invade?

Anagen

3

What are the clinical features associated with dermatophytosis?

1. Alopecic areas
2. Erythema
3. Crusts
4. Scaling
5. Hyperpigmentation
6. Broken hairs
7. Mild to moderate pruritus

4

What is furunculosis?

Open, draining tracts with serosanguinous fluid

5

What are the 3 most common causes of furunculosis?

1. Bacteria
2. Demodex
3. Dermatophytes

6

What is the most definitive, sensitive test for dermatophytosis?

Fungal culture

7

What are your systemic therapy options for dermatophytosis?

1. Azoles
2. Griseofulvin
3. Lufenuron
4. Terbinafine

8

What are the potential side effects of griseofulvin?

1. Teratogenesis
2. GI disturbance
3. Anorexia
4. Bone marrow suppression

9

What is the mechanism of action of the azoles?

Inhibit lanosterol-14 alpha-demthylase, which is responsible for forming ergosterol, a component of the fungal cell wall.

10

What are the potential side effects associated with Ketoconazole?

1. Anorexia
2. Diarrhea
3. Weight loss
4. Increased hepatic enzyme concentrations
5. Alopecia

11

Why does Ketoconazole have a lot of adverse interactions with other drugs?

It inhibits the P-glycoprotein efflux pump (brain, liver, GI)

12

True or False: Ketoconazoles penetrates readily into areas such as the CNS, eyes, and prostate.

FALSE - they penetrate these areas poorly

13

Which of these drugs is best given with a meal to increase absorption: Ketoconazole or Griseofulvin?

BOTH

14

What is the mechanism of action of Itraconazole?

Inhibits ergosterol synthesis

15

Is Itraconazole fungistatic or fungicidal?

Fungistatic

16

What are the adverse effects associated with Itraconazole?

1. Vomiting
2. Anorexia
3. Increased hepatic enzyme concentrations

17

Which of the following should be avoided in pregnant animals: Ketoconazole, Griseofulvin, or Itraconazole?

Griseofulvin & Itraconazole

18

Which of the following is classified as a triazole: Ketoconazole, Itraconazole, Griseofulvin, or Fluconazole?

Itraconazole & Fluconazole

19

Which of the following is the best for penetration into tissues such as the CSF, eye, and claws: Ketoconazole, Itraconazole, Griseofulvin, or Fluconazole?

Fluconazole

20

What are the adverse effects associated with Fluconazole?

1. Increased hepatic enzymes
2. Teratogenesis

21

Is Terbinafine fungistatic or fungicidal?

Fungicidal

22

What is the mechanism of action of Terbinafine?

Inhibits squalene epoxidase necessary for ergosterol synthesis.

23

What are the side effects associated with Terbinafine?

Relatively few side effects: elevated ALT concentration in 1/3 of cats treated.

24

Is Dermatophytosis contagious?

YES

25

Is Dermatophytosis infectious?

YES

26

Is Dermatophytosis zoonotic?

YES