DCM - Dilated Cardiomyopathy Flashcards Preview

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Flashcards in DCM - Dilated Cardiomyopathy Deck (20):
1

What is the primary etiology of DCM?

Not enough contractility

2

What gene is mutated in dobermans that predisposes them to DCM?

PDK 4

3

What are the 5 secondary causes of DCM phenotype?

1. Nutritional (taurine/carnitine) deficiency
2. Infection/inflammation
3. Tachycardia-induced
4. Sepsis-induced
5. Doxyrubicin cardiotoxicity

4

How does DCM effect systolic function?

Decreases systolic function

5

How does DCM effect the left ventricle?

Dilation of the LV

6

What type of arrhythmia is typical of DCM?

Ventricular arrhythmia (atrial fibrillation in advanced DCM)

7

____% of dobermans > ____ years of age develop DCM.

50% of dobermans > 6 years of age develop DCM.

8

What 7 breeds, other than the Doberman, are predisposed to developing DCM?

1. Great dane
2. Irish Wolfhound
3. Newfoundland
4. Portuguese water dog (juvenile)
5. Cocker spaniel (taurine/carnitine)
6. Dalmatian (low amino acid diet)
7. Boxer (ARVC)

9

Which is more predisposed to developing DCM, males or females?

Males

10

What is the gold standard in diagnosing DCM?

Holter (>50 VPC / 24 hrs)

11

What 2 things would you find on echocardiography of a dog with DCM?

1. Increased LV size (dilation)

2. Decreased LV systolic function

3. 1+ VPC / 5 minutes

12

What 2 biomarkers can help you diagnose DCM?

1. Increased NT-proBNP (>450 pmol/L)

2. Increased cTnl (>0.22 ng/mL)

13

What 2 drugs have been shown to prolong time from asymptomatic DCM to CHF?

1. Pimobendan

2. ACE inhibitor

14

What 2 drugs would you use to treat a ventricular arrhythmia?

1. Sotalol

2. Mexiletine

15

What 2 drugs would you use to treat atrial fibrillation?

1. Digoxin

2. Diltiazem

16

What does ARVC stand for?

Arrhythmogenic right ventricular cardiomyopathy

17

What is ARVC a disease of?

Desmosomes

18

What is the typical signalment of a dog with ARVC?

Middle-aged Boxer

19

How would you diagnose ARVC?

1. Holter

2. ECG

20

How would you treat ARVC?

1. Sotalol

2. Mexiletine