Antimicrobials III Flashcards Preview

Board Review - B - Systems Pharmacology > Antimicrobials III > Flashcards

Flashcards in Antimicrobials III Deck (40)
1

azithromycin

macrolide

2

clarithromycin

macrolide

3

erythromycin

macrolide

4

macrolide

inhibit 23S rRNA of 50S subunit

5

coverage macrolides

atypical pneumoniase
STDs
URIs

6

adverse macrolides

QT prolongation
GI issues
rash
eosinophilia

7

clarithromycin and erythromycin

inhibit P450

8

resistance of macrolides

methylate 23S rRNA binding site

9

trimetroprim

inhibit bacterial DHFR

used combo with sulfonamide
-sequential block folate synthesis

10

tx of UTI

TMP-SMX

11

adverse trimethoprim

megaloblastic anemia
leukopenia
granulocytopenia

12

sulfamethoxazole

sulfonamide

13

sulfisoxazole

sulfonamide

14

sulfadiazine

sulfonamide

15

sulfonamide

inhibit folate synthesis

PABA antimetabolite - inhibit dihydropteroate synthase

16

tx of leprosy

dapsone

inhibits folate synthesis

17

adverse sulfonamide

hemolysis - if G6PD deficient

nephrotoxic
photosensitivity
kernicterus
displace other drugs from albumin (warfarin)

18

resistance sulfonamides

altered enzyme
-bacterial dihydropteroate synthase

19

ciprofloxacin

fluoroquinolone

20

norfloxacin

fluoroquinolone

21

levofloxacin

fluoroquinolone

22

ofloxacin

fluoroquinolone

23

moxifloxacin

fluoroquinolone

24

gemifloxacin

fluoroquinolone

25

enoxacin

fluoroquinolone

26

fluoroquinolone

inhibit prokaryote topoisomerase II
-DNA gyrase

and topoisomerase IV

don't take with antacids

27

coverage fluoroquinolone

gram neg rods of urinary and GI tract

some gram positive organs

28

adverse fluoroquinolone

GI upset
skin rash
HA/dizzy
leg cramp, myalgia

29

CI in pregnant women

fluoroquinolone

30

tendonitis and tendon rupture

fluoroquinolone

31

damage cartilage of children

fluoroquinolone

32

daptomycin

lipopeptide

disrupt cell membrane of gram positive cocci

33

coverage daptomycin

staph aureus skin infection

bacteremia
endocarditis
VRE

34

not used for pneumonia

daptomycin
-avidly binds and inactivated by surfactant

35

adverse daptomycin

myopathy
rhabdomyolysis

36

metrondiazole

form toxic free rad metabolite
-damage DNA

bactericidal and antiprotozoal

37

coverage metrondiazole

giardia
entamoeba
trichomonas
gardnerella vaginalis
anaerobes

38

triple therapy h. pylori

metrondiazole
PPI
clarithromycin

39

anaerobic infection below diaphragm

metrondiazole

40

adverse metrondiazole

flushing, tachy, hypotension - with alcohol

HA and metallic taste