Neuro III Flashcards Preview

Board Review - B - Systems Pharmacology > Neuro III > Flashcards

Flashcards in Neuro III Deck (36)
1

succinylcholine

depolarizing agent

strong ACh agonist - resistance acetylcholinesterase

2

succinylcholine blockade phases

phase 1- prolonged depolarization - no antidote

phase 2 - repolarized but blocked - ACh receptor available but desensitized - antidote - cholinesterase inhibitor

3

adverse succinylcholine

hyperCa
hyperK
malignant hyperthermia

4

tubocurarine

nondepolarizing muscular blockage

5

atracurium

nondepolarizing muscular blockage

6

pancuronium

nondepolarizing muscular blockage

7

vecuronium

nondepolarizing muscular blockage

8

rocuronium

nondepolarizing muscular blockage

9

nondepolarizing muscular blockage

competitive antagonist - compete for ACh at receptors

reversal - neostigmine - with atropine - to prevent muscarinic effects - bradycardia

also - edrophonium and other cholinesterase inhibitor

10

dantrolene

prevent release Ca from SR of skeletal m

tx of malignant hyperthermia and neuroleptic malignant syndrome

11

baclofen

inhibit GABA-B - at spinal cord

skeletal m relaxation

12

cyclobenzaprine

central acting skeletal m relaxant

tx muscle spasms

13

bromocriptine

ergot dopamine agonist

14

pramipexole

non-ergot dopamine agonist

15

ropinirole

non-ergot dopamine agonist

16

amantadine

increase dopamine availability

increased DA release
decreased DA uptake

antiviral - influenza A and rubella

17

adverse amantadine

livedo reticularis

18

carbidopa

decreased peripheral conversion L-dopa

inhibit DOPA decarboxylase

19

entacapone

prevent peripheral L-dopa metabolism

inhibit COMT

20

tolcapone

prevent peripheral L-dopa metabolism

inhibit COMT

21

selegiline

block conversion DA > 3MT
-inhibit MAO-B

MAO-B in nerve terminal - metabolize dopamine over NE and 5-HT - so inhibit - more DA available

22

benztropine

anti-muscarinic

tx tremor and rigidity of parkinsons

little effect bradykinesia

23

tolcapone

inhibit COMT - peripheral AND centrally

24

memantine

NMDA receptor antagonist

tx of alzheimers

helps prevent excitotoxicity

25

donepezil

AChE inhibitor

tx of alzheimers

26

galantamine

AChE inhibitor

tx of alzheimers

27

rivastigmine

AChE inhibitor

tx of alzheimers

28

tacrine

AChE inhibitor

tx of alzheimers

29

huntington disease NT changes

decreased GABA
decreased ACh
increased DA

30

tetrabenazine

inhibit vesicular monoamine transport - limit dopamine vesicle pack and release

tx of huntington

31

reserpine

inhibit vesicular monoamine transport - limit dopamine vesicle pack and release

tx of huntington

32

haloperidol

D2 receptor antagonist

tx of huntington

33

triptans

5-HT 1B/1D agonist

inhibit trigeminal n activation

prevent vasoactive peptide release

induce vasoconstriction

34

tx migraine

sumatriptan

35

tx cluster HAs

sumatriptan

36

adverse triptans

coronary vasospasm
-CI prinzmetal angina