Heme/Oncology II Flashcards Preview

Board Review - B - Systems Pharmacology > Heme/Oncology II > Flashcards

Flashcards in Heme/Oncology II Deck (46)
1

azathioprine

purine analog

antimetabolite

2

6-mecaptopurine

purine analog

antimetabolite

3

6-thioguanine

purine analog

antimetabolite

4

purine analog antimetabolites

decreased de novo purine synthesis

activated by HGPRT

5

increased toxicity with allopurinol and febuxostat

azathioprine and 6-MP

because metabolized by xanthine oxidase

6

cladribine

purine analog antimetabolite

7

tx of hairy cell leukemia

cladribine

8

cytarabine

pyrimidine analog - antimetabolite

inhibits DNA polymerase

9

cytarabine adverse

pancytopenia

10

5-fluorouracil

pyrimidine analog

complexes folic acid

inhibits thymidylate synthase
-decreased dTMP > decreased DNA

tx basal cell cancer, colon cancer, pancreatic cancer

11

methotrexate

folic acid analog

inhibit dihydrofolate reductase

rediced dTMP > decreased DNA

12

medical abortion

misoprostol and methotrexate

13

rescue of methotrexate

leucovorin

14

adverse methotrexate

hepatotoxic
pulmonary fibrosis
mucosal ulcers
myelosuppression

15

antimetabolites

all S phase specific

16

bleomycin

induce free rad formation
-break DNA strands

17

adverse bleomycin

pulmonary fibrosis
skin hyperpigmentation
mucositis
myelosuppression

18

dactinomycin

intercalate in DNA

for childhood tumors

19

doxorubicin

generate free radicals
-intercalate in DNA - breaks in DNA

20

adverse doxorubicin

cardiotoxicity - dilated cardiomyopathy

21

prevent cardiotoxicity with doxorubicin

dexrazoxane - iron chelating agent

22

busulfan

cross link DNA

23

adverse busulfan

pulmonary fibrosis
hyperpigmentation

24

cyclophosphamide

cross link DNA - guanine N7

require liver bioactivation

25

ifosfamide

cross link DNA - guanine N7

require liver bioactivation

26

adverse cyclophosphamide

hemorrhagic cystitis

27

prevent hemorrhagic cystitis with cyclophosphamide

mesna

thiol group binds toxic metabolites

28

carmustine

nitrosurea

29

lomustine

nitrosurea

30

semustine

nitrosurea

31

streptozocin

nitrosurea

32

nitrosurea

require bioactivation
-cross BBB

cross link DNA

tx of brain tumors

33

paclitaxel

hyperstabilize polymer microtubule in M phase

anaphase cannot occur

34

vincristine

vinka alkaloid
-bind and inhibit beta-tubulin polymerization

prevent mitotic spindle formation
-M phase arrest

35

vinblastine

vinka alkaloid
-bind and inhibit beta-tubulin polymerization

prevent mitotic spindle formation
-M phase arrest

36

adverse vincristine

neurotoxic - areflexic, peripheral neuritis

37

adverse vinblastine

bone marrow suppression

38

cisplatin

cross link DNA

39

carboplatin

cross link DNA

40

adverse cisplatin

nephrotoxicity
ototoxicity

41

reverse cisplatin nephrotoxicity

amifostine - free rad scavenger
chloride - saline diuresis

42

etoposide

inhibit topoisomerase II - more DNA degradation

43

irinotecan

inhibit topoisomerae I - prevent DNA unwinding and replication

44

topotecan

inhibit topoisomerae I - prevent DNA unwinding and replication

45

teniposide

inhibit topoisomerase II - more DNA degradation

46

hydroxyurea

inhibit ribonucleotide reductase

decreased DNA synthesis - S phase specific