Antimicrobials VI Flashcards Preview

Board Review - B - Systems Pharmacology > Antimicrobials VI > Flashcards

Flashcards in Antimicrobials VI Deck (36)
1

oseltamivir

inhibit influenza neuraminidase
-decreased release of progeny

2

tx of influenza A and B

oseltamivir
zanamivir

3

zanamivir

inhibit influenza neuraminidase
-decreased release of progeny

4

acyclovir

guanosine analog

monophosphorylated by HSV/VZV thymidine inase

triphosphate formed

inhibit viral DNA polymerase - chain termination

5

famciclovir

guanosine analog

monophosphorylated by HSV/VZV thymidine inase

triphosphate formed

inhibit viral DNA polymerase - chain termination

6

valacyclovir

guanosine analog

monophosphorylated by HSV/VZV thymidine inase

triphosphate formed

inhibit viral DNA polymerase - chain termination

7

adverse acyclovir

obstructive crystal nephropathy

8

prevent adverse of acyclovir

hydration - prevent crystal nephropathy

9

tx of HSV and VZV

acyclovir
famciclovir
valacyclovir

10

gangciclovir

5'-monophosphate formed by CMV viral kinase

guanosine analog

triphosphate formed by cellular kinases
-inhibit DNA polymerase

chain termination

11

tx of CMV

gangciclovir

12

tx for HSV encephalitis

temporal lobe

acyclovir, famciclovir, valacyclovir

13

tx genital HSV warts

acyclovir, famciclovir, valacyclovir

14

resistance acyclovir

mutated viral thymidine kinase

15

resistance gangciclovir

mutated viral kinase

16

adverse gangciclovir

leukopenia
neutropenia
thrombocytopenia
renal toxicity

more toxic than acyclovir

17

foscarnet

viral DNA/RNA polymerase inhibitor
and HIV reverse transcriptase inhibitor

binds pyrophosphate binding site of enzyme

no activation by viral kinases

18

tx of CMV retinitis

gangciclovir

if fails - foscarnet

19

resistance to foscarnet

mutated DNA polymerase

20

tx acyclovir resistant HSV

foscarnet

21

CMV

infect mononuclear cells

22

EBV

infect B cells

23

cidofovir

inhibit viral DNA polymerase
-does not require activation viral kinases

24

clinical use cidofovir

CMV retinitis - immunocompromised

acyclovir resistance HSV

25

adverse cidofovir

nephrotoxic

coadmin with probenecid and IV saline - prevent toxicity

26

HIV therapy

high active antiretroviral therapy

started - time of diagnosis of HIV infection

two NRTIs

and one of following
-NNRTI, protease inhibitor, integrase inhibitor

27

atazanavir

protease inhibitor

28

darunavir

protease inhibitor

29

fosamprenavir

protease inhibitor

30

indinavir

protease inhibitor

31

lopinavir

protease inhibitor

32

ritonavir

protease inhibitor

33

saquinavir

protease inhibitor

34

protease inhibitor

prevent maturation of new viruses

HIV-1 protease - pol gene
-cleaves polypeptide products of HIV mRNA into their functional parts

35

ritonavir boost

can enhanced other drug concentration
-inhibit P450

36

rifampin

CI with protease inhibitor - can decrease protease inhibitor concentration