Repro I Flashcards Preview

Board Review - B - Systems Pharmacology > Repro I > Flashcards

Flashcards in Repro I Deck (47)
1

leuprolide

GnRH agonist - pulsatile
GnRH antagonist - continuous

2

infertility tx

leuprolide - pulsatile

3

ethinyl estradiol

estrogen

4

DES

estrogen

5

mestranol

estrogen

6

HRT in post menopause women

estrogen

7

adverse estrogen therapy

increase risk endometrial cancer

8

exposure to DES in utero

clear cell adenocarcinoma of vagina risk

9

CI for estrogen therapy

ER+ breast cancer
history of DVTs

10

tx androgen dependent prostate cancer

estrogens

11

clomiphene

SERM
antagonist estrogen receptor in hypothalamus
-prevent normal feedback inhibition
-increased release of LH and FSH
-stimulates ovulation

12

tx infertility due to anovulation

clomiphene

13

tamoxifen

SERM
antagonist breast
agonist bone and uterus

tx and prevent recurrence ER/PR + breast cancer

14

raloxifene

SERM
antagonist breast, uterus
agonist bone

15

adverse tamoxifen

increased risk of thromboembolic event and endometrial cancer

16

aderse raloxifene

increased risk thromboembolic event

NO increased risk endometrial cancer
-antagonist at uterus

17

anastrozole

aromatase inhibitor

tx ER + breast cancer

18

exemestane

aromatase inhibitor

19

progestin

bind progesterone receptor

decreased growth and increased vasc of endometrium

20

hormone replacement therapy

relief sx of post-menopause

osteoporosis - more estrogen - decrease osteoclasts

21

unopposed estrogen therapy

increased risk endometrial cancer
-so combine with progesterone

22

mifepristone

RU-486

competitive inhibitor of progestins at progesterone receptor

23

termination of pregnancy

mifepristone - RU-486 - progesterone receptor inhibitor
misoprostol - PGE1 - prostaglandin

24

oral contraception

estrogen and progestins
-inhibit LH/FSH - prevent estrogen surge
-no LH surge - no ovulation

progestins - also - thick cervical mucus and inhibit endometrial proliferation

25

CI for oral contraception

smoker >35yo
hx of thromboembolism or stroke

26

terbutaline

beta2 agonist

relax uterus contractions

27

ritodrine

beta2 agonist

relax uterus contraction

28

danazol

synthetic androgen
-partial agonist at androgen receptor

29

adverse danazol

hirsutism, acne, masculinization, weight gain, edema

30

testosterone

agonist androgen receptors

31

tx hypogonadism and promote secondary sex characters in boy

testosterone

32

adverse testosterone

gonadal atrophy

premature closure epiphyseal plates- short stature

33

finasteride

5a reductase inhibitor
-no peripheral T > DHT

34

tx BPH and male pattern baldness

finasteride

35

flutamide

nonsteroid competitive inhibitor at androgen receptors

tx prostate carcinoma

36

ketoconazole

inhibit steroid synthesis

inhibit 17,20 desmolase

37

spironolactone

inhibit steroid binding, 17a hydroxylase, and 17,20 desmolase

38

tx of androgenic sx of PCOS

ketoconazole and spironolactone

39

tamsulosin

a1 antagonist
-selective for a1-AD - in prostate

smooth muscle relaxation

40

tx of BPH

tamsulosin

smooth muscle relax in prostate

41

sildenafil

PDE5 inhibitor

42

vardenafil

PDE5 inhibitor

43

tadalafil

PDE5 inhibitor

44

PDE5 inhibitor

increased cGMP, smooth m relaxation corpus cavernosum

increased blood flow - erection

45

adverse PDE5 inhibitor

HA, flush, dyspepsia, cyanopsia (blue tint vision)

46

life threatening hypotension

if give nitrate and PDE5 inhibitor together

47

minoxidil

direct arteriolar vasodilator

tx of androgenetic alopecia and severe refractory HTN