Repro I Flashcards

(47 cards)

1
Q

leuprolide

A

GnRH agonist - pulsatile

GnRH antagonist - continuous

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2
Q

infertility tx

A

leuprolide - pulsatile

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3
Q

ethinyl estradiol

A

estrogen

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4
Q

DES

A

estrogen

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5
Q

mestranol

A

estrogen

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6
Q

HRT in post menopause women

A

estrogen

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7
Q

adverse estrogen therapy

A

increase risk endometrial cancer

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8
Q

exposure to DES in utero

A

clear cell adenocarcinoma of vagina risk

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9
Q

CI for estrogen therapy

A

ER+ breast cancer

history of DVTs

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10
Q

tx androgen dependent prostate cancer

A

estrogens

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11
Q

clomiphene

A
SERM
antagonist estrogen receptor in hypothalamus
-prevent normal feedback inhibition
-increased release of LH and FSH
-stimulates ovulation
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12
Q

tx infertility due to anovulation

A

clomiphene

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13
Q

tamoxifen

A

SERM
antagonist breast
agonist bone and uterus

tx and prevent recurrence ER/PR + breast cancer

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14
Q

raloxifene

A

SERM
antagonist breast, uterus
agonist bone

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15
Q

adverse tamoxifen

A

increased risk of thromboembolic event and endometrial cancer

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16
Q

aderse raloxifene

A

increased risk thromboembolic event

NO increased risk endometrial cancer
-antagonist at uterus

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17
Q

anastrozole

A

aromatase inhibitor

tx ER + breast cancer

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18
Q

exemestane

A

aromatase inhibitor

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19
Q

progestin

A

bind progesterone receptor

decreased growth and increased vasc of endometrium

20
Q

hormone replacement therapy

A

relief sx of post-menopause

osteoporosis - more estrogen - decrease osteoclasts

21
Q

unopposed estrogen therapy

A

increased risk endometrial cancer

-so combine with progesterone

22
Q

mifepristone

A

RU-486

competitive inhibitor of progestins at progesterone receptor

23
Q

termination of pregnancy

A

mifepristone - RU-486 - progesterone receptor inhibitor

misoprostol - PGE1 - prostaglandin

24
Q

oral contraception

A

estrogen and progestins

  • inhibit LH/FSH - prevent estrogen surge
  • no LH surge - no ovulation

progestins - also - thick cervical mucus and inhibit endometrial proliferation

25
CI for oral contraception
smoker >35yo | hx of thromboembolism or stroke
26
terbutaline
beta2 agonist relax uterus contractions
27
ritodrine
beta2 agonist relax uterus contraction
28
danazol
synthetic androgen | -partial agonist at androgen receptor
29
adverse danazol
hirsutism, acne, masculinization, weight gain, edema
30
testosterone
agonist androgen receptors
31
tx hypogonadism and promote secondary sex characters in boy
testosterone
32
adverse testosterone
gonadal atrophy premature closure epiphyseal plates- short stature
33
finasteride
5a reductase inhibitor | -no peripheral T > DHT
34
tx BPH and male pattern baldness
finasteride
35
flutamide
nonsteroid competitive inhibitor at androgen receptors tx prostate carcinoma
36
ketoconazole
inhibit steroid synthesis inhibit 17,20 desmolase
37
spironolactone
inhibit steroid binding, 17a hydroxylase, and 17,20 desmolase
38
tx of androgenic sx of PCOS
ketoconazole and spironolactone
39
tamsulosin
a1 antagonist -selective for a1-AD - in prostate smooth muscle relaxation
40
tx of BPH
tamsulosin smooth muscle relax in prostate
41
sildenafil
PDE5 inhibitor
42
vardenafil
PDE5 inhibitor
43
tadalafil
PDE5 inhibitor
44
PDE5 inhibitor
increased cGMP, smooth m relaxation corpus cavernosum increased blood flow - erection
45
adverse PDE5 inhibitor
HA, flush, dyspepsia, cyanopsia (blue tint vision)
46
life threatening hypotension
if give nitrate and PDE5 inhibitor together
47
minoxidil
direct arteriolar vasodilator tx of androgenetic alopecia and severe refractory HTN