Repro I Flashcards
(47 cards)
leuprolide
GnRH agonist - pulsatile
GnRH antagonist - continuous
infertility tx
leuprolide - pulsatile
ethinyl estradiol
estrogen
DES
estrogen
mestranol
estrogen
HRT in post menopause women
estrogen
adverse estrogen therapy
increase risk endometrial cancer
exposure to DES in utero
clear cell adenocarcinoma of vagina risk
CI for estrogen therapy
ER+ breast cancer
history of DVTs
tx androgen dependent prostate cancer
estrogens
clomiphene
SERM antagonist estrogen receptor in hypothalamus -prevent normal feedback inhibition -increased release of LH and FSH -stimulates ovulation
tx infertility due to anovulation
clomiphene
tamoxifen
SERM
antagonist breast
agonist bone and uterus
tx and prevent recurrence ER/PR + breast cancer
raloxifene
SERM
antagonist breast, uterus
agonist bone
adverse tamoxifen
increased risk of thromboembolic event and endometrial cancer
aderse raloxifene
increased risk thromboembolic event
NO increased risk endometrial cancer
-antagonist at uterus
anastrozole
aromatase inhibitor
tx ER + breast cancer
exemestane
aromatase inhibitor
progestin
bind progesterone receptor
decreased growth and increased vasc of endometrium
hormone replacement therapy
relief sx of post-menopause
osteoporosis - more estrogen - decrease osteoclasts
unopposed estrogen therapy
increased risk endometrial cancer
-so combine with progesterone
mifepristone
RU-486
competitive inhibitor of progestins at progesterone receptor
termination of pregnancy
mifepristone - RU-486 - progesterone receptor inhibitor
misoprostol - PGE1 - prostaglandin
oral contraception
estrogen and progestins
- inhibit LH/FSH - prevent estrogen surge
- no LH surge - no ovulation
progestins - also - thick cervical mucus and inhibit endometrial proliferation