MSK II Flashcards Preview

Board Review - B - Systems Pharmacology > MSK II > Flashcards

Flashcards in MSK II Deck (19)
1

teriparatide

recombinant PTH analog

give subQ daily

increased osteoblast activity

2

clinical use teriparatide

osteoporosis

cause increased bone growth

3

teriparatide adverse

transient hyperCa

increased risk osteosarcoma possible

4

allopurinol

inhibit xanthine oxidase

decrease conversion xanthine > uric acid

5

prevention tumor lysis syndrome

allopurinol

6

febuxostat

inhibit xanthine oxidase

7

pegloticase

recombinant uricase
-catalyze metabolism uric acid > allantoin (water soluble)

8

probenecid

inhibit reabsorption uric acid proximal convoluted tubule

can precipitate uric acid calculi

9

adverse probenecid

precipitate uric acid calculi

10

chronic gout tx

prevention

allopurinol
febuxostat
pegloticase
probenecid

11

acute gout tx

NSAID
glucocorticoid
colchicine

12

colchicine

bind and stabilize tubulin
-inhibit microtubule polymerization
-impair neutrophil chemotaxis and degranulation

13

adverse colchicine

don't give salicylates

all but highest doses depress uric acid clearance

14

TNF-a inhibitors

all predispose to infection

reactivate latent TB - TNF needed to stabilize granuloma

15

etanercept

TNF-a inhibitor

fusion protein
-receptor for TNF-a + IgG1 Fc

16

infliximab

anti-TNF-a monoclonal Ab

17

adalimumab

anti-TNF-a monoclonal Ab

18

tx rheumatoid arthritis, psoriasis, ankylosing spondylitis

etancercept

19

tx IBD, rheumatoud arthritis, ankylosing spondylitis, psoriasis

infliximab
adaliumuab