Neuro I Flashcards Preview

Board Review - B - Systems Pharmacology > Neuro I > Flashcards

Flashcards in Neuro I Deck (54)
1

tx of glaucoma

decreased aqueous humor synthesis:
a-agonists
B-blockers
diuretic - acetazolamide

increased aqueous humor outflow:
cholinomimetic
prostaglandin

2

epinephrine

a1 agonist

tx of glaucoma

3

brimonidine

a2 agonist

tx of glaucoma

4

tx emergency glaucoma

pilocarpine - opening meshwork into canal of schlemm

increased outflow -contract ciliary muscle

5

timolol

B-blocker

tx of glaucoma

6

betaxolol

B-blocker

tx of glaucoma

7

carteolol

B-blocker

tx of glaucoma

8

pilocarpine

direct cholinomimetic

tx of glaucoma

9

carbachol

direct cholinomimetic

tx of glaucoma

10

physostigmine

indirect cholinomimetic

tx of glaucoma

11

echothiophate

indirect cholinomimetic

tx of glaucoma

12

latanoprost

PGF2a - prostaglandin

tx of glaucoma - increased outflow aqueous humor

13

adverse latanoprost

darken color of iris - browning

14

morphine

opioid agonist

15

fentanyl

opioid agonist

16

codeine

opioid agonist

17

loperamide

opioid agonist

18

meperidine

opioid agonist

19

dextromethorphan

opioid agonist

20

diphenoxylate

opioid agonist

21

pentazocine

opioid agonist

22

MOA opioid

agonist at mu, delta, kappa receptors

open K channel, close Ca channel - decreased synaptic transmission

inhibit release ACh, NE, 5-HT, glutamate, substance P

23

methadone

long half life opioid

tx of opioid abuse

24

adverse opioid

abuse - miosis

25

tolerance and opioid

not to miosis or constipaion

26

naloxone

opioid antagonist

27

naltrexone

opioid antagonist

28

butorphanol

kappa-opioid agonist
mu opioid partial agonist

can cause opioid withdrawal in those taking full opioid agonist

29

tramadol

weak opioid agonist
inhibit 5-HT and NE reuptake

decreased seizure threshold compared to opioids

30

ethosuximide

block thalamic T-type Ca channels

31

tx of absence seizure

ethosuximide

32

adverse ethosuximide

stevens johnson syndrome

HA, itching, fatigue, GI distress

33

tx acute status epilepticus

benzos - diazepam and lorazepam

34

benzo MOA

increased GABA-A action

35

tx for eclampsia seizure

MgSO4 - 1st line

also benzos

36

first line tx tonic clonic seizures

phenytoin
carbamazepine
valproic acid

37

phenytoin

increase Na channel inactivation

zero-order kinetics

38

adverse phenytoin

gingival hyperplasia
teratogen
induce P450
stevens johnson

39

first line tx trigeminal neuralgia

carbamazepine

40

carbamazepine

increased Na channel inactivation

41

adverse carbamazepine

agranulocytosis, aplastic anemia
liver toxicity
teratogen

CYP inducer
stevens johnson

42

valproic acid

increased Na channel inactivation
increased GABA concentration - inhibit GABA transaminase

43

adverse valproic acid

neural tube defect - CI in pregnancy

hepatoxicity

44

gabapentin

inhibit high voltage activated Ca channel

GABA analog

epilepsy drug -partial seizures

45

phenobarbitol

increased GABA-A action
1st line in neonates

46

adverse phenobarbitol

sedation
tolerance
dependence
induction P450

47

topiramate

block Na channel
increased GABA activity

48

migraine prevention

topiramate

49

lamotrigine

block voltage gated Na channels

50

adverse lamotrigine

steven johnson syndrome

51

levetiracetam

epilepsy drug

modulate GABA and glutamate release

52

tiagabine

increased GABA - inhibit uptake

epileptic drug

53

vigabatrin

increased GABA - inrreversible inhibition GABA transaminase

epileptic drug

54

steven johnson syndrome

prodrome - malaise and fever
-rapid onset itchy erythematous rashes
-skin lesions progress skin necrosis and sloughing