Heme/Oncology I Flashcards Preview

Board Review - B - Systems Pharmacology > Heme/Oncology I > Flashcards

Flashcards in Heme/Oncology I Deck (48)
1

heparin

activator of antithrombin

decreased thrombin and factor Xa - anticoagulant

2

immediate anticoagulation

heparin

3

monitor with heparin

PTT

4

HIT

heparin induce thrombocytopenia

IgG Abs against heparin bound platelet factor 4 (PF4)

Ab-heparin-HP4 - activate platelet - thrombosis and thrombocytopenia

5

argatroban

thrombin inhibitor

6

bivalirudin

thrombin inhibitor

7

dabigatran

thrombin inhibitor

8

protamine sulfate

reversal of heparin

positive charbe - binds negative heparin

9

enoxaparin

LMWH

10

dalteparin

LMWH

11

fondaparinux

LMWH

12

LMWH

act more on factor Xa
-better bioavailability

longer half life

no lab monitoring
not reversible

13

warfarin

interfere with gamma carboxylation vit K factors

II, VII, IX, X, protein C and S

14

monitor with warfarin

PT and INR

15

chronic anticoag

warfarin

16

warfarin pregnancy

no - teratogen

17

transient hypercoag with warfarin

protein C and S - shorter half lives
-so get hypercoag when start warfarin therapy

18

reversal of warfarin

vit K

19

rapid reversal of warfarin

fresh frozen plasma

20

heparin bridging

heparin used when starting warfarin
-to get anticoag during transient hypercoag of warfarin use

21

apixaban

direct factor Xa inhibitor

22

rivaroxaban

direct factor Xa inhibitor

23

alteplase

thrombolytic

24

reteplase

thrombolytic

25

streptokinase

thrombolytic

26

tenecteplase

thrombolytic

27

thrombolytics

aid conversion plasminogen to plasmin

plasmin - cleaves thrombin and fibrin clots

28

changes with thrombolytic therapy

increased PT and PTT
no change platelet count

29

adverse thrombolytic

bleeding

CI if pt with recent bleeding

30

aminocaproic acid

tx of thrombolytic toxicity
-inhibitor of fibrinolysis

31

aspirin

irreversible COX inhibitor

covalent acetylation

32

changes with aspirin therapy

increased bleeding time
decreased TXA2 and PGs

no effect PT and PTT

33

adverse aspirin

tinnitus - CN VIII
gastric ulcer
upper GI bleed
interstitial nephritis

reye syndrome

34

reye syndrome

child with viral infection - takes aspirin

35

acid-base status with aspirin OD

hyperventilation - respiratory alkalosis

eventual mixed with metabolic acidosis

36

clopidogrel

ADP receptor inhibitor

37

prasugrel

ADP receptor inhibitor

38

ticagrelor

ADP receptor inhibitor

39

ticlopidine

ADP receptor inhibitor

40

ADP receptor inhibitors

inhibit platelet aggregation
-irreversible block ADP receptor
-prevent expression glycoprotein IIb/IIIa

41

adverse ticlopidine

neutropenia

42

cliostazol

phosphodiesterase inhibitor
-increased cAMP in platelets
-inhibit platelet aggregation

vasodilator

43

dipyrimadole

phosphodiesterase inhibitor

vasodilator

44

adverse of phosphodiesterase inhibitors

nausea, headache, flushing, hypotension, abdomen pain

45

abciximab

GP IIb/IIIa inhibitor

46

eptifibatide

GP IIb/IIIa inhibitor

47

tirofiban

GP IIb/IIIa inhibitor

48

GP IIb/IIIa inhibitor

prevent platelet aggregation