Neuro II Flashcards Preview

Board Review - B - Systems Pharmacology > Neuro II > Flashcards

Flashcards in Neuro II Deck (46)
1

phenobarbitol

barbituate

2

pentobarbital

barbituate

3

thiopental

barbituate

4

secobarbital

barbituate

5

barbiutate

facilitate GABA-A action
-increased DURATION of Cl- channel opening

decrease neuroin firing

bArbituAte - durAtion

6

adverse barbituate

resp/cardiac depression

P450 inducer

OC - supportive tx

7

chlordiazepoxide

benzodiazepine

8

benzodiazepine

faciliate GABA-A activityion
-increase FREQUENCY of Cl- channel opening

bEnzo - frEquEncy

9

short acting benzos

ATOM

alprazolam
triazolam
oxazepam
midazolam

higher risk of addiction

10

adverse benzos

dependence
CNS depression - with alcohol

11

tx OD benzos

flumazenil

12

flumazenil

competitive antagonist at GABA benzo receptor

13

zolpidem

non-benzo hypnotic

14

zaleplon

non-benzo hypnotic

15

eszopiclone

non-benzo hypnotic

16

non-benzo hypnotics

activia BZ1 subtype GABA receptor

effect - reversed by flumazenil

17

MAC

minimal alveolar concentration
-to prevent 50% subjects response to painful stimuli

measure of potency

18

anesthetic decreased solubility in blood

rapid induction and recovery

19

anesthetic increased solubility in lipid

increased potency

20

nitrous oxide

low blood and lipid solubility
-fast induction - low potency

21

halothane

high blood and lipid solubility
-slow induction - high potency

22

halothane

inhaled anesthetic
unknown MOA

23

enflurane

inhaled anesthetic
unknown MOA

24

isoflurane

inhaled anesthetic
unknown MOA

25

sevoflurane

inhaled anesthetic
unknown MOA

26

methoxyflurane

inhaled anesthetic
unknown MOA

27

N2O

inhaled anesthetic
unknown MOA

28

malignant hyperthermia

with inhaled anesthetic and succinycholine

hyperthermia and muscle contraction

tx - dantrolene

29

tx malignant hyperthermia

dantrolene - acts on RyR

30

thiopental metabolism

terminated action
-by REDISTRIBUTION to tissues

31

tx OD benzo

flumazenil

32

midazolam

MC drug for anesthesia during endoscopy

33

ketamine

arylcyclohexylamine

PCP analog - dissociative anesthetic

block NMDA receptor

cardiovasc stimulant
-disorientation, hallucinations, bad dreams

34

propofol

for sedation in ICU
-rapid anesthesia induction

potentiate GABA-A

35

procaine

ester local anesthetic

36

cocaine

ester local anesthetic

37

tetracaine

ester local anesthetic

38

lidocaine

amide local anesthetic

39

mepivicaine

amide local anesthetic

40

bupivicaine

amide local anesthetic

41

local anesthetic

block Na channels
-bind receptors on inner portion of channels

prefer bind activated Na channels

sometimes given with vaosoconstrictor - epinephrine

42

infected acidic tissue

need more anesthetic

43

order of nerve blockade speed

small diameter faster
myelinated faster
size over myelination

small myelinated > small unmyelinated > large myelinated > large unmyelinated

44

order of loss with local anesthetic

1 pain
2 temp
3 touch
4 pressure

45

adverse benzocaine

methemoglobinemia

46

adverse bupivicaine

cardiovascular toxicity