Antimicrobials I Flashcards Preview

Board Review - B - Systems Pharmacology > Antimicrobials I > Flashcards

Flashcards in Antimicrobials I Deck (49)
1

PCN G

IV/IM form

2

PCN V

oral form

3

penicillin

bind PCN-binding protein - transpeptidase
-blocks crosslinking peptidoglycan

4

coverage of PCN

gram positive organisms
gram neg cocci - neisseria meningitidis
spirochetes - t. pallidum

5

resistance to PCN

penicillinase - beta-lactamase

cleaves beta lactam ring

6

amoxicillin

penicillinase sensitive PCN
-aminopenicillin

7

ampicillin

penicillinase sensitive PCN
-aminopenicillin

8

coverage of amoxicillin and ampicillin

HHELPSS

h. flu
h. oylori
e. coli
listeria
proteus
salmonella
shigella

9

HHELPS

coverage amoxicillin and ampicillin

h. flu
h. oylori
e. coli
listeria
proteus
salmonella
shigella

10

adverse of amoxicillin/ampicillin

pseudomembranous colitis

11

rash with amoxicillin or ampicillin

consider underlying mononucleosis infection

aminoPCN rxn

12

dicloxacillin

penicillinase resistant penicillin

13

nafcillin

penicillinase resistant penicillin

14

oxacillin

penicillinase resistant penicillin

15

penicillinase resistant penicillin

resistant to penicillinase - bc of bulky R group
blocks access of beta-lactamase

16

coverage of penicillin resistant penicillins

staph aureus

not MRSA

17

piperacillin

antipseudomonal

18

ticarillin

antipseudomonal

19

antipseudomonals

penicillin mechanism of action

20

coverage antipseudomonals

pseudomonas
gram neg rods
susceptible to penicillinase

use with beta-lactam inhibitor

21

clavulinic acid

beta-lactamase inhibitor

22

sulbactam

beta-lactamase inhibitor

23

tazobactam

beta-lactamase inhibitor

24

beta-lactamase inhibitors

add to PCN antibiotics - to protect antibiotic from destruction by beta-lactamase

25

tx syphilis

PCN G

26

tx UTI

amoxicillin

27

tx neonatal listeria/group B strep

ampicillin

28

tx resistant otitis media

amoxicillin and clavulinic acid

29

cephalosporin

beta-lactam drug
-inhibit cell wall synthesis
-less susceptible to penicillinases

30

not covered by cephalosporin

LAME

listeria
atypicals
mycoplasma
enterococci

31

cefazolin

1st gen cephalosporin

32

cephalexin

1st gen cephalosporin

33

generation of cephalosporins

as get to further generation
-more gram negative coverage
-less gram positive coverage

34

1st generation cephalosporin gram coverage

gram positive
proteus
e. coli
klebsiella

35

PeCK coverage

1st gen cephalosporins

proteus
e. coli
klebsiella

36

cefoxitin

2nd gen cephalosporin

37

cefaclor

2nd gen cephalosporin

38

cefuroxime

2nd gen cephalosporin

39

2nd gen cephalosporin coverage

HEN PEcKS

h. fluc
enterobacter aerogenes
neisseria
proteus
e. coli
klebsiella
serratia

40

ceftriaxone

3rd gen cephalosporin

41

cefotaxime

3rd gen cephalosporin

42

ceftazidime

3rd gen cephalosporin

43

3rd gen cephalosporin coverage

serious gram negatives

ceftriaxone - meningitis, gonorrhea, disseminated lyme
ceftazidine - pseudomonas

44

tx disseminated lyme

ceftriaxone

45

ceftaroline

5th gen cephalosporin

46

5th gen cephalosporin coverage

broad gram positive and gram negative

does not cover pseudomonas

47

pseudomonas cephalosporin

covered by cefepime - 4h generation

48

cefepime

4th gen cephalosporin

49

increased nephrotoxicity of aminoglycosides

with cephalosporins