Antimicrobials V Flashcards Preview

Board Review - B - Systems Pharmacology > Antimicrobials V > Flashcards

Flashcards in Antimicrobials V Deck (51)
1

nystatin

bind ergosterol - form pores

2

nystatin clinical use

topical only - too toxic for systemic

diaper rash or vaginal candidiasis

3

oral candidiasis

swish and swallow nystatin

4

flucytosine

inhibit DNA and RNA biosynthesis
-convert to 5-FU by cytosine deaminase

5

adverse flucytosine

bone marrow suppression

6

clinical use flucytosine

crypto meningitis
-in combo with amphotericin B

7

clotrimazole

azole

8

fluconazole

azole

9

itraconazole

azole

10

ketoconazole

azole

11

miconazole

azole

12

voriconazole

azole

13

azole

inhibit fungal sterol (ergosterol) synthesis

inhibit P450 enzyme that converts lanosterol > ergosterol

14

other tx for blastomyces

itraconazole

15

other tx of coccidioides

itraconazole

16

other tx of histoplasma

itraconazole

17

chronic suppression of cryptococcal meningitis in AIDS patients

fluconazole

18

topical fungal infection tx

clotrimazole
miconazole

19

adverse azole

testosterone synthesis inhibition - gynecomastia

liver dysfxn - inhibit P450

20

terbinafine

inhibit fungal enzyme squalene epoxidase

stop conversion squalene > squalene epoxide
-precursor in synthesis of ergosterol

21

tx of onychomycosis

fungal infection under finger/toe nails

terbinafine

22

adverse terbinafine

GI upset
HA
hepatotoxic
taste disturbance

23

anidulafungin

echinocandin

24

caspofugin

echinocandin

25

micafungin

echinocandin

26

echinocandin

inhibit cell wal lsynthesisi - inhibit synthesis of beta-glucan

27

ergosterol

in cell MEMBRANE

amphotericin B and nystatin poke hole

28

cell wall of fungi

inhibited by echinocandin

-caspofungin, micafungin, anidulafungin

29

griseofulvin

interfere microtubule fxn
-disrupt mitosis

deposit in keratin containing tissues

30

ora tx for dermatophytes

griseofulvin

tinea, ringworm, etc.

31

tx toxoplasmosis

pyrimethamine

32

tx trypanosoma brucei

suramin
melarsoprol

33

tx t. cruzi

nifurtimox

34

tx leishmaniasis

sodium stibogluconate

35

permethrin

block Na channel - neurotoxic

36

malathion

acetylcholinesterae inhibitor

37

lindane

inhibit GABA - neurotoxic

38

tx for scabies

permerthrin
malathion
lindane

39

lice

pediculus
pthirus

tx - permethrin, malathion, lindane

40

chloroquine

block detoxification of heme into hemozoin
-heme accumulate - toxic to plasmodia

41

tx of plasmodium infections

chloroquine

42

adverse chloroquine

retinopathy
pruritis - dark skinned individuals

43

plasmodium falciprum

high resistance
-so tx with chloroquine doesn't work

44

resistance to chloroquine

membrane pump - decrease intracellular concentration of drug

45

tx of p. falciprum

artemether/lumefantrine
atovaquone/proguanil

46

tx life-threatening malaria

quinidine or artesunate

47

mebendazole

anti-helminth tx

48

pyrantel pamoate

anti-helminth tx

49

ivermectin

anti-helminth tx

50

diethylcarbamazine

anti-helminth tx

51

praziquantel

anti-helminth tx