Psych I Flashcards Preview

Board Review - B - Systems Pharmacology > Psych I > Flashcards

Flashcards in Psych I Deck (47)
1

tx ADHD

stimulants - methylphenidate

2

tx alcohol withdrawal

long acting benzo
-chlordiazepam, lorazepam, diazepam

3

tx bipolar

lithium
valproic acid
atypical antipsychotics

4

tx bulimia

SSRI

5

tx depression

SSRI

6

tx GAD

SSRI
SNRI

7

tx OCD

SSRI
clomipramine

8

tx panic disorder

SSRI
venlafaxine
benzos

9

tx PTSD

SSRI
venlafaxine

10

tx schizophrenia

atypical antipsychotics

11

tx social phobia

SSRI
beta-blockers

12

tx tourette

antipsychotic
tetrabenazine
clonidine

13

methylphenidate

CNS stimulant - increased catecholamine at synaptic cleft

NE and DA

14

dextroamphetamine

CNS stimulant - increased catecholamine at synaptic cleft

NE and DA

15

methamphetamine

CNS stimulant - increased catecholamine at synaptic cleft

NE and DA

16

typical antipsychotics

neuroleptics

all block dopamine D2 receptors - increased cAMP

17

haloperidol

typical antipsychotic

18

trifluoperazine

typical antipsychotic

19

fluphenazine

typical antipsychotic

20

thioridiazine

typical antipsychotic

21

chlorpromazine

typical antipsychotic

22

high potency typical antipsychotic

trifluoperazine
fluphenazine
haloperidol

neuro side effects - huntington, extrapyramidal

23

low potency typical antipsychotic

chlorpromazine
thioridazine

non - neuro side effects - anticholinergic, antihistmaine, a1 block

24

adverse chlorpromazine

corneal deposits

25

adverse thioridazine

retinal deposits

26

adverse haloperidol

NMS
tardive dyskinesia

27

endocrine defect with typical antipsychotics

dopamine receptor antagonist
-hyperPRL
-galactorrhea

28

neuroleptic malignant syndrome

rigid, myoglobinuria, autonomic instable, hyperpyrexia
-with typical antipsychotic use

tx - dantrolene or bromocriptine (D2 agonist)

29

olanzapine

atypical psychotic

30

clozapine

atypical psychotic

31

quetiapine

atypical psychotic

32

risperidone

atypical psychotic

33

aripiprazole

atypical psychotic

34

ziprasidone

atypical psychotic

35

atypical psychotic MOA

not completely understood

variable effect - 5HT2, DA, alpha and H1 receptors

36

schizophrenia tx

positive sx - typical antipsychotic
positive and negative sx - atypical antipsychotic

37

tardive dyskinesia

with long term antipsychotic use

oral-facial movements

38

adverse clozapine

weight gain
agranulocytosis
seizure

39

risperidone adverse

increased PRL - lactation and gynecomastia

40

lithium

mood stabilizer for bipolar

block relapse and acute manic events

41

adverse lithium

tremor
hypothyroid
polyuria - nephrogenic DI
teratogenesis

ebstein anomaly in newborn - pregnant mother use

42

ebstein anomaly

congenital heart defect
-septal and posterior leaflets of tricupsid valve
-displaced toward apex right ventricle

43

narrow therapeutic window

lithium

44

lithium pharmacodynamics

narrow therapy window
-close serum monitoring

excreted by kidneys - reabsorbed at PCT with Na

45

tx lithium toxicity

thiazide diuretic

46

buspirone

stimulate 5-HT1A receptors

tx GAD

takes 1-2 weeks to take effect

47

takes 1-2 weeks to get clinical effect

buspirone for tx of GAD