Heme/Oncology III Flashcards Preview

Board Review - B - Systems Pharmacology > Heme/Oncology III > Flashcards

Flashcards in Heme/Oncology III Deck (35)
1

prednisone

bind intracytoplasmic - alter gene expression

MC glucocorticoid in cancer chemotherapy

2

adverse prednisone

cushing like syndrome
-weight gain, central obesity, muscle breakdown, cataract, acne, osteoporosis, HTN

3

bevacizumab

monoclonal Ab - VEGF

inhibit angiogenesis

4

erlotinib

EGFR tyrosine kinase inhibitor

tx - non small cell lung ca

adverse - rash

5

adverse bevacizumab

hemorrhage

VEGF mAb

6

imatinib

tyrosine kinase BCR-ABL inhibitor and c-kit inhibitor

7

clinical imatinib

CML - BCR-ABL
GI stromal tumor - c-kit

tyrosine kinase inhibitor

8

rituximab

monoclonal Ab - CD20 - B cell neoplasms

9

adverse rituximab

progressive multifocal leukencephalopathy

10

tamoxifen

selective estrogen receptor modulator - SERM

11

raloxifene

selective estrogen receptor modulator - SERM

12

SERM

selective estrogen receptor modulator

antagonist breast
agonist bone

13

tx breast cancer and prevent osteoporosis

tamoxifen

14

tamoxifen adverse

agonist endometrium - increased risk endometrial caner

15

raloxifene adverse

no increase in endometrial carcinoma

is estrogen receptor antagonist

16

trastuzumab

monoclonal Ab - Her-2 - tyrosine kinase receptor

tx of Her-2 positive breast cancer and gastric cancer

17

adverse trastuzumab

cardiotoxicity

18

vemurafenib

small molecule inhibitor BRAF oncogene

tx of melanoma

19

tx metastatic melanoma

vemurafenib

20

acoustic nerve damage

cisplatin
carboplatin

21

peripheral neuropathy

vincristine

22

pulmonary fibrosis

bleomycin
busulfan

23

cardiotoxicity

doxorubicin
trastuzumab

24

nephrotoxic

cisplatin
carboplatin

25

hemorrhagic cystitis

cyclophosphamide

26

myelosuppression

5-FU
6-MP
methotrexate

27

cell phase bleomycin

G2

28

cell phase paclitaxel

M

29

cell phase vinblastine

M

30

cell phase vincristine

M

31

cell phase cisplastin

G1

32

cell phase 5-FU

S

33

cell phase 6-MP

S

34

cell phase MTX

S

35

cell phase hydroxyurea

S