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Flashcards in Female Genital/Breast Deck (54)
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1

pap smear credited with reduction of which cancer?

cervical carcinoma

2

most important agent in cervical oncogenesis

HPV

3

low risk HPV serotypes

6,11

4

high risk HPV serotypes

16,18

5

HPV interferes with which tumor suppressor gene?

p53

6

which quadrivalent vaccine confers immunity to HPV types 16 & 18 (70% of cervical cancer) and 6 & 11 (90% of condyloma acuminatum)

gardasil

7

cervical carcinoma preceded by precancerous (dysplastic) lesion

cervical intraepithelial neoplasia

8

peak incidence of cervical carcinoma

40-45 years

9

"genital warts", sexually transmitted and benign, multiple, HPV types 6 & 11

condyloma acuminatum

10

STD caused by the spirochete treponema pallidum; main diagnostic tests: VDRL and RPR

syphilis

11

presence of a chancre at the site of initial inoculation; small papule which enlarges into a painless ulcer with well-defined margins and clean moist base

primary syphilis

12

generalized lymphadenopathy and a variety of mucocutaneous lesions; lesions can be maculopapular, scaly or pustular; involvement of palms and soles common; typically within 2 months of resolution of the chancre

secondary syphilis

13

usually after a latent period of 5 yrs or more; 3 categories: cardiovascular, neuro, benign; gummas are focal granulomatous lesions that can occur in multiple organs

tertiary syphilis

14

common STD, purulent cervicitis typically develops 2-7 days after exposure; vaginal discharge, painful intercourse, dysuria; easily treated with antibiotics

gonorrhea

15

nongonococcal cervicitis; most commonly reported bacterial STD; caused by a small G-

chlamydia (c. trachomatis)

16

most common cause of abnormal vaginal discharge; thin, milky vaginal discharge, foul fishy odour; gardenella vaginalis

bacterial vaginosis

17

eukaryotic organism, parasitic protozoa, STD, burning, itching, malodorous vaginal discharge, can usually be seen on PAP smear

trichomonas vaginalis

18

most common vaginal and cervical fungal infection; predominantly as yeast buds and forms pseudohyphae

candida

19

most common in patients using intrauterine contraceptive devices

actinomyces

20

ground glass nuclei, eosinophilic intranuclear inclusions

herpes

21

both intranuclear (basophilic) and cytoplasmic inclusions

cytomegalovirus

22

pelvic pain, adnexal tenderness, fever, vaginal discharge, may induce formation of tubo-ovarian abscess/pyosalpinx; oophoritis, salpingitis; gonococci and chlamydia

pelvic inflammatory disease

23

also called Stein-Leventhal syndrome; numerous cystic follicles; enlarged ovaries twice their normal size

polycystic ovarian disease

24

the presence of glands or endometrial stroma in an abnormal location outside uterus; a disorder of reproductive years; responds to hormonal stimulation

endometriosis

25

common cause of abnormal bleeding; linked to prolonged estrogen stimulation

endometrial hyperplasia

26

most common invasive carcinoma of the female genital tract; predominately a disease of postmenopausal women; "post-menopausal bleeding"

endometrial carcinoma

27

tumor of smooth muscle; common during reproductive years; may induce spontaneous aportion

leiomyoma

28

malignant counterpart of leiomyoma with necrosis

leiomyosarcoma

29

second most common cancer of the female genital tract: 3 % of all cancers in women

ovarian cancer

30

account for a disproportionate number of fatal cancers due to presentation at late stage; often asymptomatic until late stages; elevations in CA-125

ovarian cancer